State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Acta Biomater. 2024 Jun;181:67-97. doi: 10.1016/j.actbio.2024.04.037. Epub 2024 Apr 30.
Sonodynamic therapy (SDT), utilizing ultrasound (US) as the trigger, has gained popularity recently as a therapeutic approach with significant potential for treating various diseases. Metal-organic frameworks (MOFs), characterized by structural flexibility, are prominently emerging in the SDT realm as an innovative type of sonosensitizer, offering functional tunability and biocompatibility. However, due to the inherent limitations of MOFs, such as low reactivity to reactive oxygen species and challenges posed by the complex tumor microenvironment, MOF-based sonosensitizers with singular functions are unable to demonstrate the desired therapeutic efficacy and may pose risks of toxicity, limiting their biological applications to superficial tissues. MOFs generally possess distinctive crystalline structures and properties, and their controlled coordination environments provide a flexible platform for exploring structure-effect relationships and guiding the design and development of MOF-based nanomaterials to unlock their broader potential in biological fields. The primary focus of this paper is to summarize cases involving the modification of different MOF materials and the innovative strategies developed for various complex conditions. The paper outlines the diverse application areas of functionalized MOF-based sonosensitizers in tumor synergistic therapies, highlighting the extensive prospects of SDT. Additionally, challenges confronting SDT are briefly summarized to stimulate increased scientific interest in the practical application of MOFs and the successful clinical translation of SDT. Through these discussions, we strive to foster advancements that lead to early-stage clinical benefits for patients. STATEMENT OF SIGNIFICANCE: 1. An overview for the progresses in SDT explored from a novel and fundamental perspective. 2. Different modification strategies to improve the MOFs-mediated SDT efficacy are provided. 3. Guidelines for the design of multifunctional MOFs-based sonosensitizers are offered. 4. Powerful tumor ablation potential is reflected in SDT-led synergistic therapies. 5. Future challenges in the field of MOFs-based SDT in clinical translation are suggested.
声动力学疗法（SDT）利用超声（US）作为触发手段，最近作为一种具有治疗各种疾病巨大潜力的治疗方法越来越受欢迎。金属有机框架（MOFs）具有结构灵活性，作为一种新型声敏剂在 SDT 领域崭露头角，提供功能可调性和生物相容性。然而，由于 MOFs 的固有局限性，例如对活性氧的反应性低以及复杂肿瘤微环境带来的挑战，具有单一功能的 MOF 基声敏剂无法表现出所需的治疗效果，并且可能存在毒性风险，限制了它们在浅层组织中的生物应用。MOFs 通常具有独特的晶体结构和性质，其受控的配位环境为探索结构-效应关系和指导 MOF 基纳米材料的设计和开发提供了一个灵活的平台，以释放其在生物领域的更广泛潜力。本文的主要重点是总结涉及不同 MOF 材料的改性和为各种复杂条件开发的创新策略的案例。本文概述了功能化 MOF 基声敏剂在肿瘤协同治疗中的多样化应用领域，突出了 SDT 的广泛前景。此外，还简要总结了 SDT 面临的挑战，以激发科学界对 MOF 的实际应用和 SDT 的成功临床转化的更大兴趣。通过这些讨论，我们努力推动进展，为患者带来早期临床获益。重要性声明：1. 从新颖和基础的角度探索 SDT 的进展概述。2. 提供了改善 MOF 介导的 SDT 疗效的不同改性策略。3. 提供了设计多功能 MOF 基声敏剂的指南。4. 反映了 SDT 引导的协同治疗中的强大肿瘤消融潜力。5. 提出了 MOF 基 SDT 在临床转化领域的未来挑战。
