School of Public Health, University College Cork, 4th Floor, Western Gateway Building, Western Road, Cork, Ireland.
National Cancer Registry Ireland, Cork, Ireland.
Qual Life Res. 2021 Sep;30(9):2509-2520. doi: 10.1007/s11136-021-02831-3. Epub 2021 Apr 1.
Information concerning the health-related quality-of-life (HRQoL) consequences of colposcopy is limited, particularly over time. In a longitudinal study, we investigated women's HRQoL at 4, 8 and 12 months post colposcopy and the factors associated with this.
Women attending colposcopy at two large hospitals affiliated with the national screening programme in Ireland were invited to complete questionnaires at 4, 8 and 12 months post colposcopy. HRQoL was measured using the EQ-5D-3L and compared across a range of socio-demographic, clinical and attitudinal variables. A mixed-effects logistic multivariable model was employed to investigate associations between these variables and low HRQoL.
Of 584 women initially recruited, 429, 343 and 303 completed questionnaires at 4, 8 and 12 months, respectively. The mean overall HRQoL score for the sample across all time points was 0.90 (SD 0.16). Approximately 18% of women experienced low HRQoL at each of the three time points. In multivariable testing, over the entire 12-month follow-up period, non-Irish nationals (OR 8.99, 95% CI 2.35-34.43) and women with high-grade referral cytology (OR 2.78, 95% CI 1.08-7.13) were at higher odds of low HRQoL. Women who were past (OR 0.20, 95% CI 0.07-0.58) or never (OR 0.42, 95% CI 0.16-1.12) smokers were at lower odds of low HRQoL than current smokers. As women's satisfaction with their healthcare increased their odds of experiencing low HRQoL fell (OR per unit increase 0.51, 95% CI 0.34-0.75).
Women's HRQoL did not change over the 12 months post colposcopy, but some subgroups of women were at higher risk of experiencing low HRQoL. These subgroups may benefit from additional support.
有关阴道镜检查对健康相关生活质量（HRQoL）影响的信息有限，特别是随着时间的推移。在一项纵向研究中，我们调查了女性阴道镜检查后 4、8 和 12 个月的 HRQoL 及其相关因素。
在爱尔兰国家筛查计划下的两家大医院接受阴道镜检查的女性被邀请在阴道镜检查后 4、8 和 12 个月填写问卷。使用 EQ-5D-3L 测量 HRQoL，并与一系列社会人口统计学、临床和态度变量进行比较。采用混合效应逻辑多变量模型调查这些变量与低 HRQoL 之间的关联。
在最初招募的 584 名女性中，429 名、343 名和 303 名分别在 4、8 和 12 个月时完成了问卷。样本在所有时间点的总体 HRQoL 平均得分为 0.90（SD 0.16）。大约 18%的女性在三个时间点都经历了低 HRQoL。在多变量测试中，在整个 12 个月的随访期间，非爱尔兰国民（OR 8.99，95%CI 2.35-34.43）和高级转诊细胞学（OR 2.78，95%CI 1.08-7.13）的女性发生低 HRQoL 的可能性更高。过去（OR 0.20，95%CI 0.07-0.58）或从未（OR 0.42，95%CI 0.16-1.12）吸烟的女性发生低 HRQoL 的可能性低于当前吸烟者。随着女性对医疗保健的满意度增加，她们经历低 HRQoL 的可能性降低（OR 每单位增加 0.51，95%CI 0.34-0.75）。
女性的 HRQoL 在阴道镜检查后 12 个月内没有变化，但某些亚组女性发生低 HRQoL 的风险更高。这些亚组可能需要额外的支持。
