Australian Women and Girls' Health Research Centre, School of Public Health, Faculty of Medicine, The University of Queensland, 266 Herston Road, Brisbane, Queensland 4006, Australia.
Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Road, Brisbane, Queensland 4072, Australia.
Maturitas. 2023 Aug;174:1-7. doi: 10.1016/j.maturitas.2023.04.272. Epub 2023 May 6.
To examine the association between endometriosis and women's health-related quality of life (HRQoL).
This study included 3728 women born in 1973-78 using data from the Australian Longitudinal Study on Women's Health. Women with endometriosis were identified using self-reported longitudinal surveys linked to administrative health records. A mixed effect model with only random intercept and generalised estimating equations with binary logistic regressions were used to examine the association between endometriosis and health-related quality of life over eight time points. Each HRQoL scale was analysed in terms of binary outcomes by comparing women who had a lower HRQoL (scoring below the 25th percentile) with those who had a higher HRQoL (scoring above the 25th percentile).
Women's HRQoL was assessed using the 36-item Short Form Survey every 3 years from 1996 to 2018.
Endometriosis was associated with significantly worse reports of HRQoL over time. In the comparison against women without endometriosis, the following adjusted odds ratios (95 % confidence intervals) were calculated for women with endometriosis having worse scores on the eight domains of the Short Form Survey: physical functioning 1.33 (1.19, 1.50), role physical 1.57 (1.41, 1.74), bodily pain 1.65 (1.48, 1.82), general health 1.61 (1.42, 1.81), vitality 1.38 (1.23, 1.55), social functioning 1.38 (1.25, 1.53), role emotion 1.19 (1.06, 1.33), mental health 1.32 (1.18, 1.48). Women with endometriosis also had significantly lower physical health 1.68 (1.51, 1.88) and mental health components scores 1.28 (1.14, 1.44).
Endometriosis is associated with worse physical, mental, and social functioning and well-being. Bodily pain was the most affected HRQoL domain.
探讨子宫内膜异位症与女性健康相关生活质量（HRQoL）之间的关系。
本研究纳入了 1973-78 年出生的 3728 名女性，数据来自澳大利亚女性健康纵向研究。通过与行政健康记录相关联的纵向自我报告调查，确定患有子宫内膜异位症的女性。使用仅随机截距的混合效应模型和二项逻辑回归的广义估计方程，来检查 8 个时间点子宫内膜异位症与健康相关生活质量之间的关联。通过将 HRQoL 评分较低（低于第 25 百分位数）的女性与 HRQoL 评分较高（高于第 25 百分位数）的女性进行比较，从二分结果的角度分析每个 HRQoL 量表。
使用 36 项简短表格调查，每 3 年从 1996 年到 2018 年评估女性的 HRQoL。
子宫内膜异位症与随着时间推移 HRQoL 报告的显著恶化有关。与没有子宫内膜异位症的女性相比，患有子宫内膜异位症的女性在 36 项简短表格调查的八个领域中得分更差，其调整后的比值比（95%置信区间）为：身体功能 1.33（1.19，1.50），身体角色 1.57（1.41，1.74），身体疼痛 1.65（1.48，1.82），一般健康 1.61（1.42，1.81），活力 1.38（1.23，1.55），社会功能 1.38（1.25，1.53），情绪角色 1.19（1.06，1.33），心理健康 1.32（1.18，1.48）。患有子宫内膜异位症的女性也有显著较低的身体健康评分 1.68（1.51，1.88）和心理健康评分 1.28（1.14，1.44）。
子宫内膜异位症与身体、心理和社会功能及幸福感下降有关。身体疼痛是受影响最严重的 HRQoL 领域。
