Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College , Huazhong University of Science and Technology , Wuhan 430030 , China.
Org Lett. 2019 Feb 15;21(4):1026-1030. doi: 10.1021/acs.orglett.8b04066. Epub 2019 Feb 7.
Amichalasines A-C (1-3), which represent a new type of cytochalasan heterotrimers, were isolated from Aspergillus micronesiensis PG-1. Compounds 1 and 2 possess an undecacyclic 5/6/11/5/5/6/6/5/11/6/5 ring system, and 3 has an additional furan ring with a dodecacyclic 5/6/11/5/5/6/6/5/5/11/6/5 ring system. 1 and 2 exhibited potent cytotoxic activities through apoptosis induction mediated by caspase-3 activation and PARP degradation, and their IC values against HL60 cells were 1.71 and 3.74 μM, respectively.
阿米卡星 A-C（1-3）是从米氏曲霉 PG-1 中分离得到的一种新型细胞松弛素杂三聚体。化合物 1 和 2 具有十一元环 5/6/11/5/5/6/6/5/11/6/5 环系，而 3 具有一个呋喃环，其具有十二元环 5/6/11/5/5/6/6/5/5/11/6/5 环系。1 和 2 通过 caspase-3 激活和 PARP 降解介导的细胞凋亡诱导表现出强烈的细胞毒性活性，其对 HL60 细胞的 IC50 值分别为 1.71 和 3.74 μM。
