茶米素A，一种来自内生真菌黑曲霉F5的具有三环核心骨架的细胞松弛素。
Chamiside A, a Cytochalasan with a Tricyclic Core Skeleton from the Endophytic Fungus Chaetomium nigricolor F5.
作者信息
Wang Hang-Hang, Li Gang, Qiao Ya-Nan, Sun Yong, Peng Xiao-Ping, Lou Hong-Xiang
机构信息
Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy , Qingdao University , Qingdao 266021 , People's Republic of China.
Department of Natural Product Chemistry, Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences , Shandong University , Jinan 250012 , People's Republic of China.
出版信息
Org Lett. 2019 May 3;21(9):3319-3322. doi: 10.1021/acs.orglett.9b01065. Epub 2019 Apr 15.
Chamiside A (1), a novel cytochalasan with a new 6/6/5-fused tricyclic core skeleton, was isolated from an endophytic fungus, Chaetomium nigricolor F5, harbored in the medicinal plant Mahonia fortunei. Its structure was unambiguously determined by extensive spectroscopic analyses, measurement of single-crystal X-ray diffraction, and electronic circular dichroism calculation. A biosynthetic pathway for the unique ring system in 1 was proposed. Compound 1 exhibited moderate antibacterial activity against Staphylococcus aureus.
茶米素A（1）是一种具有新型6/6/5稠合三环核心骨架的新型细胞松弛素，它是从药用植物十大功劳中内生真菌黑毛壳菌F5中分离得到的。通过广泛的光谱分析、单晶X射线衍射测量和电子圆二色性计算，明确确定了其结构。提出了1中独特环系的生物合成途径。化合物1对金黄色葡萄球菌表现出中等抗菌活性。
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