Zou Xiaojuan, Fan Zhongqi, Zhao Ling, Xu Weiling, Zhang Jin, Jiang Zhenyu
Department of Rheumatology, The First Hospital of Jilin University, Changchun, 130012, Jilin, China.
Department of Hepatobiliary Pancreatic Surgery, The First Hospital of Jilin University, Changchun, 130012, China.
BMC Gastroenterol. 2021 Apr 1;21(1):148. doi: 10.1186/s12876-021-01736-2.
Antiphospholipid syndrome (APS) is an acquired pre-thrombotic autoimmune condition, which produces autoantibodies called antiphospholipid antibodies (APL) against phospholipid-binding plasma proteins. The diagnosis of APS requires at least one of Sapporo standard clinical manifestations and one laboratory criteria (persistently medium/high titer anticardiolipin antibodies, and/or medium/high titer anti-β2-glycoprotein I antibodies, and/or a positive lupus anticoagulant test). Gastrointestinal lesions are rarely reported in APS patients. APS cases with recurrent abdominal pain as the first clinical manifestation are even rarer.
This report describes an APS case with recurrent abdominal pain as the first clinical manifestation of antiphospholipid syndrome. The patient has a history of two miscarriages. Computed tomography of the abdomen confirmed mesenteric thrombosis and intestinal obstruction while laboratory tests for serum antiphospholipid and anti-β2-glycoprotein I antibodies were positive. This led to the diagnosis of APS.
This paper provides useful information on gastrointestinal manifestations and APS, also including a brief literature review about possible gastrointestinal symptoms of APS.
抗磷脂综合征（APS）是一种获得性血栓前自身免疫性疾病，可产生针对磷脂结合血浆蛋白的自身抗体，称为抗磷脂抗体（APL）。APS的诊断需要至少一项札幌标准临床表现和一项实验室标准（持续中/高滴度抗心磷脂抗体，和/或中/高滴度抗β2-糖蛋白I抗体，和/或狼疮抗凝物试验阳性）。胃肠道病变在APS患者中很少见。以反复腹痛为首发临床表现的APS病例更为罕见。
本报告描述了一例以反复腹痛为抗磷脂综合征首发临床表现的APS病例。该患者有两次流产史。腹部计算机断层扫描证实存在肠系膜血栓形成和肠梗阻，而血清抗磷脂和抗β2-糖蛋白I抗体的实验室检查呈阳性。这导致了APS的诊断。
本文提供了有关胃肠道表现和APS的有用信息，还包括一篇关于APS可能的胃肠道症状的简要文献综述。
