Agency for Toxic Substances and Disease Registry, Atlanta, Georgia.
National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia.
J Expo Sci Environ Epidemiol. 2021 Nov;31(6):961-971. doi: 10.1038/s41370-021-00316-6. Epub 2021 Apr 1.
The National Center for Environmental Health (NCEH), part of the Centers for Disease Control and Prevention (CDC), and the Agency for Toxic Substances and Disease Registry (ATSDR) support and conduct research advancing national, state, and local public health response to per- and polyfluoroalkyl substances (PFAS). PFAS are a group of manufactured chemicals used in industry and consumer products that persist in the environment. Given the growing evidence linking PFAS with adverse health effects in humans, NCEH and ATSDR developed a public health research framework to capture the broad range of PFAS research activities being conducted and supported by the agency to determine future research priorities and identify opportunities for interagency collaboration. The framework was conceptualized via a multidisciplinary visioning process designed to identify compelling questions and research activities that span five scientific domains: toxicology, exposure, human health, public health action, and cross-cutting priorities. This paper presents a framework, compelling questions and research activities to help NCEH and ATSDR advance scientific discovery in partnership with federal, state, and local stakeholders as part of a comprehensive public health response to PFAS contamination.
国家环境卫生中心（NCEH）是疾病控制与预防中心（CDC）的一部分，以及毒物与疾病登记署（ATSDR）支持并开展研究，以推进国家、州和地方公共卫生部门应对全氟和多氟烷基物质（PFAS）的措施。PFAS 是一组用于工业和消费产品的人造化学品，在环境中持久存在。鉴于越来越多的证据将 PFAS 与人类健康的不良影响联系起来，NCEH 和 ATSDR 制定了一个公共卫生研究框架，以捕捉该机构正在进行和支持的广泛的 PFAS 研究活动，以确定未来的研究重点，并确定机构间合作的机会。该框架是通过一个多学科的构想过程来构想的，旨在确定跨五个科学领域的引人注目的问题和研究活动：毒理学、暴露、人类健康、公共卫生行动和交叉优先事项。本文提出了一个框架、引人注目的问题和研究活动，以帮助 NCEH 和 ATSDR 与联邦、州和地方利益相关者合作，推进科学发现，作为对 PFAS 污染的全面公共卫生应对的一部分。
