Marasca Claudio, Fabbrocini Gabriella, Abategiovanni Luisa, Camela Elisa, Nocerino Mariateresa, Di Guida Adriana, De Fata Salvatores Gaia
Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Skin Appendage Disord. 2021 Feb;7(2):115-119. doi: 10.1159/000512032. Epub 2021 Jan 21.
Acne fulminans (AF) is a rare, acute, and severe form of acne vulgaris often associated with systemic symptoms. Its treatment is challenging and controversial. We report a case of isotretinoin-induced AF (IIAF) in a 12-year-old boy resistant to traditional therapies (oral steroids and isotretinoin). The patient was successfully treated with adalimumab that can be considered an effective off-label option in the treatment of resistant IIAF in children.
暴发性痤疮（AF）是寻常痤疮的一种罕见、急性且严重的形式，常伴有全身症状。其治疗具有挑战性且存在争议。我们报告了一例12岁男孩的异维A酸诱发的暴发性痤疮（IIAF），该患儿对传统疗法（口服类固醇和异维A酸）耐药。该患者通过阿达木单抗成功治愈，阿达木单抗可被视为治疗儿童耐药性IIAF的一种有效的非标签用药选择。
