Thiam Chiann Ni, Hasmukharay Kejal, Lim Wan Chieh, Ng Chai Chen, Pang Gordon Hwa Mang, Abdullah Aimy, Saedon Nor Izzati, Khor Hui Min, Ong Terence
Department of General Medicine, Hospital Kuala Lumpur, Ministry of Health, Jalan Pahang, Kuala Lumpur 50586, Malaysia.
Geriatric Medicine Unit, Department of Medicine, University Malaya Medical Centre, Kuala Lumpur 59100, Malaysia.
Geriatrics (Basel). 2021 Mar 8;6(1):25. doi: 10.3390/geriatrics6010025.
(1) Background: Older people with COVID-19 infection report worse clinical outcomes. There is a paucity of local data and this study aimed to describe the clinical progression of older people admitted to a university hospital in Malaysia with COVID-19 infection. (2) Methods: Older people (≥60 years) admitted with COVID-19 infection confirmed with RT-PCR from 27 February 2020-25 May 2020 were included in this study. Data on patient characteristics, hospital treatment, and inpatient outcomes were collected via hospital-held electronic medical records. Analysis was done to describe the cohort and identify factors associated with inpatient mortality. (3) Results: 26 participants were included (mean age 76.2 years, female 57.7%). All had at least one comorbid condition and half were frail. About 19.2% had non-respiratory (atypical) symptoms; 23.1% had a severe disease that required intensive care unit monitoring; 46.2% were given COVID-19 targeted therapy. Inpatient mortality and overall complication rates were 23.1% and 42.3%, respectively. Delirium on presentation and lower Ct-value were associated with mortality. (4) Conclusions: Older people with COVID-19 infection have severe infection and poor hospital outcomes. Vigilant hospital care is necessary to address their multimorbidity and frailty, along with appropriate treatment for their infection.
（1）背景：感染新型冠状病毒肺炎（COVID-19）的老年人临床结局较差。当地数据匮乏，本研究旨在描述马来西亚一家大学医院收治的感染COVID-19的老年人的临床病程。（2）方法：纳入2020年2月27日至2020年5月25日期间因COVID-19感染入院且经逆转录聚合酶链反应（RT-PCR）确诊的老年人（≥60岁）。通过医院保存的电子病历收集患者特征、医院治疗及住院结局的数据。进行分析以描述该队列并确定与住院死亡率相关的因素。（3）结果：纳入26名参与者（平均年龄76.2岁，女性占57.7%）。所有人都至少有一种合并症，半数身体虚弱。约19.2%有非呼吸道（非典型）症状；23.1%患有需要重症监护病房监测的严重疾病；46.2%接受了针对COVID-19 的治疗。住院死亡率和总体并发症发生率分别为23.1%和42.3%。入院时谵妄和较低的Ct值与死亡率相关。（4）结论：感染COVID-19的老年人感染严重且住院结局不佳。需要警惕的医院护理来应对他们的多种合并症和身体虚弱状况，同时对其感染进行适当治疗。
