Jinga Sorin-Ion, Anghel Ana-Maria, Brincoveanu Silvia-Florena, Bucur Raluca-Maria, Florea Andrei-Dan, Saftau Bianca-Irina, Stroe Stefania-Cristina, Zamfirescu Andreea-Ioana, Busuioc Cristina
Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, RO-011061 Bucharest, Romania.
Faculty of Medical Engineering, University POLITEHNICA of Bucharest, RO-011061 Bucharest, Romania.
Materials (Basel). 2021 Mar 21;14(6):1532. doi: 10.3390/ma14061532.
Three different inorganic scaffolds were obtained starting from the oxide system SiO‒PO‒CaO‒MgO, to which Ce/Sm/Sr cations were added in order to propose novel materials with potential application in the field of hard tissue engineering. Knowing the beneficial effects of each element, improved features in terms of mechanical properties, antibacterial activity and cellular response are expected. The compositions were processed in the form of scaffolds by a common sol-gel method, followed by a thermal treatment at 1000 and 1200 °C. The obtained samples were characterized from thermal, compositional, morphological and mechanical point of view. It was shown that each supplementary component triggers the modification of the crystalline phase composition, as well as microstructural details. Moreover, the shrinkage behavior is well correlated with the attained compression strength values. Sm was proven to be the best choice, since in addition to a superior mechanical resistance, a clear beneficial influence on the viability of 3T3 fibroblast cell line was observed.
从氧化物体系SiO-PO-CaO-MgO出发，获得了三种不同的无机支架，并向其中添加了Ce/Sm/Sr阳离子，以提出在硬组织工程领域具有潜在应用价值的新型材料。鉴于每种元素的有益作用，预计这些材料在机械性能、抗菌活性和细胞反应方面会有改进。通过常见的溶胶-凝胶法将这些组合物加工成支架形式，随后在1000℃和1200℃下进行热处理。从热学、成分、形态和力学角度对所得样品进行了表征。结果表明，每种添加成分都会引发晶相组成以及微观结构细节的改变。此外，收缩行为与所获得的抗压强度值密切相关。事实证明，Sm是最佳选择，因为除了具有优异的机械抗性外，还观察到对3T3成纤维细胞系的活力有明显的有益影响。
