不同运动方式对非酒精性脂肪肝影响的 Meta 分析和 Meta 回归。

Effect of Different Exercise Methods on Non-Alcoholic Fatty Liver Disease: A Meta-Analysis and Meta-Regression.

机构信息

Division of Sports Science and Physical Education, Tsinghua University, Beijing 100081, China.

School of Kinesiology and Health, Huaihua University, Huaihua 418000, China.

出版信息

Int J Environ Res Public Health. 2021 Mar 21;18(6):3242. doi: 10.3390/ijerph18063242.

Exercise could alleviate non-alcoholic fatty liver disease (NAFLD), but it was not clear which exercise methods could effectively treat NAFLD. The purpose of this systematic review and meta-analysis was to evaluate the effects of different exercise patterns on eight indicators in patients with NAFLD. We searched PubMed, Scopus, Web of Science, China National Knowledge Infrastructure, and the Wanfang Data from its inception to 30 June 2020. This review includes all randomized controlled trials (RCT) that assessed and compared the effects of different exercise on eight indicator parameters in patients with NAFLD. The results indicate that aerobic exercises could significantly improve the eight indicators in patients with NAFLD including triglycerides (TG, weighted mean difference (WMD) = -0.53, 95%CI: -0.68~~-0.39, Z = 7.37, < 0.01), total cholesterol (TC, WMD = -0.39, 95%CI: -0.55~~-0.23, Z = 4.76, < 0.01), low density lipoprotein (LDL, WMD = -0.47, 95%CI: -0.68~~-0.26, Z = 4.33, < 0.01), high density lipoprotein (HDL, WMD = 0.12, 95%CI: 0.05~~0.18, Z = 3.56, < 0.01), alanine aminotransferase (ALT, WMD = -6.14, 95%CI: -10.99~~-1.29, Z = 2.48, < 0.05), aspartate aminotransferase (AST, WMD = -5.73, 95%CI: -9.08~~-2.38, Z = 3.36, < 0.01), and body mass index (BMI, WMD = -0.85, 95%CI: -1.19~~-0.51, Z = 4.92, < 0.01). Resistance exercises could significantly reduce the levels of TG (WMD = -0.56, 95%CI: -0.85~~-0.28, Z = 3.86, < 0.01) and AST (WMD = -2.58, 95%CI: -4.79~~-0.36, Z = 2.28, < 0.05) in the patients. High-intensity interval training could significantly improve the level of ALT (WMD = -6.20, 95%CI: -9.34~~-3.06, Z = 3.87, < 0.01) in patients with NAFLD. These three exercise methods had different effects on the eight indexes of NAFLD in our present meta-analysis, providing some reference for the establishment of exercise prescription for patients with NAFLD.

运动可以缓解非酒精性脂肪性肝病（NAFLD），但哪种运动方式能有效治疗 NAFLD 尚不清楚。本系统评价和荟萃分析的目的是评估不同运动方式对 NAFLD 患者 8 项指标的影响。我们检索了 PubMed、Scopus、Web of Science、中国知网和万方数据，检索时间截至 2020 年 6 月 30 日。本综述包括所有评估和比较不同运动对 NAFLD 患者 8 项指标影响的随机对照试验（RCT）。结果表明，有氧运动可显著改善 NAFLD 患者的 8 项指标，包括甘油三酯（TG，WMD=-0.53，95%CI：-0.68~~-0.39，Z=7.37， < 0.01）、总胆固醇（TC，WMD=-0.39，95%CI：-0.55~~-0.23，Z=4.76， < 0.01）、低密度脂蛋白（LDL，WMD=-0.47，95%CI：-0.68~~-0.26，Z=4.33， < 0.01）、高密度脂蛋白（HDL，WMD=0.12，95%CI：0.05~~0.18，Z=3.56， < 0.01）、丙氨酸氨基转移酶（ALT，WMD=-6.14，95%CI：-10.99~~-1.29，Z=2.48， < 0.05）、天冬氨酸氨基转移酶（AST，WMD=-5.73，95%CI：-9.08~~-2.38，Z=3.36， < 0.01）和体重指数（BMI，WMD=-0.85，95%CI：-1.19~~-0.51，Z=4.92， < 0.01）。抗阻运动可显著降低 TG（WMD=-0.56，95%CI：-0.85~~-0.28，Z=3.86， < 0.01）和 AST（WMD=-2.58，95%CI：-4.79~~-0.36，Z=2.28， < 0.05）水平。高强度间歇训练可显著改善 ALT（WMD=-6.20，95%CI：-9.34~~-3.06，Z=3.87， < 0.01）水平。这三种运动方式对本荟萃分析中 NAFLD 的 8 项指标有不同的影响，为 NAFLD 患者运动处方的制定提供了一定的参考。