溴化乙锭和萘啶酸预处理对透射电子显微镜（TEM）和马来酰肼在蚕豆主根分生组织中诱导染色单体畸变的影响。
Effects of ethidium bromide and nalidixic acid pretreatment on the induction of chromatid aberrations by TEM and maleic hydrazide in Vicia faba main root meristems.
作者信息
Michaelis A, Rieger R, Nicoloff H
机构信息
Zentralinstitut für Genetic und Kulturpflanzenforschung der AdW der D.D.R., Gatersleben.
出版信息
Mutat Res. 1988 Jun;208(2):83-6. doi: 10.1016/s0165-7992(98)90004-5.
Pretreatment of Vicia faba main root meristems with ethidium bromide (EB) or nalidixic acid (NA) significantly reduced the yield of metaphases with chromatid aberrations induced by maleic hydrazide (MH), i.e., triggered clastogenic adaptation to MH. No such protection occurred when the alkylating agent triethylenemelamine (TEM) was used for challenge treatment. The differential response of pretreated cells to MH on the one hand (protection) and to TEM (no protection) on the other supports the conclusion that clastogenic adaptation is due to different inducible (repair?) functions, which eventually exert protection against clastogenic impacts.
用溴化乙锭（EB）或萘啶酸（NA）对蚕豆主根分生组织进行预处理，可显著降低由马来酰肼（MH）诱导的具有染色单体畸变的中期细胞产量，即引发对MH的致断裂适应性。当使用烷基化剂三亚乙基蜜胺（TEM）进行激发处理时，未出现这种保护作用。预处理细胞对MH（保护）和对TEM（无保护）的不同反应支持了这样的结论，即致断裂适应性是由于不同的可诱导（修复？）功能，最终对致断裂影响起到保护作用。
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