新生霉素对蚕豆中热休克保护作用的影响，该保护作用针对三亚乙基三聚氰胺（TEM）和马来酰肼（MH）诱导的染色单体畸变。
Effects of novobiocin on heat shock protection against chromatid aberration induction by triethylenemelamine (TEM) and maleic hydrazide (MH) in Vicia faba.
作者信息
Nicoloff H, Rieger R, Michaelis A
机构信息
Zentralinstitut für Genetik und Kulturpflanzenforschung, Akademie der Wissenschaften der D.D.R., Gatersleben.
出版信息
Mutat Res. 1988 Jul;208(3-4):173-8. doi: 10.1016/0165-7992(88)90056-5.
Heat shock (10 min 40 degrees C) prior to challenge treatment with triethylenemelamine (TEM) or maleic hydrazide (MH) significantly reduced the frequency of induced chromatid aberrations in Vicia faba main root meristems. Novobiocin treatment before heat shock did not prevent heat shock protection against both clastogens; novobiocin application after heat shock prevented protective effects. These results and those obtained earlier for heat shock protection against X-ray challenge are used to discuss possible causes underlying the protective effects triggered by heat shock.
在用三亚乙基三聚氰胺（TEM）或马来酰肼（MH）进行激发处理之前进行热休克（40摄氏度，10分钟），可显著降低蚕豆主根分生组织中诱导的染色单体畸变频率。在热休克之前进行新生霉素处理并不能阻止热休克对两种致裂剂的保护作用；在热休克之后应用新生霉素则会阻止保护作用。这些结果以及早期获得的关于热休克对X射线激发的保护作用的结果，被用于讨论热休克触发保护作用的可能原因。
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