Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran.
Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran.
Molecules. 2021 Mar 10;26(6):1510. doi: 10.3390/molecules26061510.
The use of naturally occurring materials in biomedicine has been increasingly attracting the researchers' interest and, in this regard, gum tragacanth (GT) is recently showing great promise as a therapeutic substance in tissue engineering and regenerative medicine. As a polysaccharide, GT can be easily extracted from the stems and branches of various species of This anionic polymer is known to be a biodegradable, non-allergenic, non-toxic, and non-carcinogenic material. The stability against microbial, heat and acid degradation has made GT an attractive material not only in industrial settings (e.g., food packaging) but also in biomedical approaches (e.g., drug delivery). Over time, GT has been shown to be a useful reagent in the formation and stabilization of metal nanoparticles in the context of green chemistry. With the advent of tissue engineering, GT has also been utilized for the fabrication of three-dimensional (3D) scaffolds applied for both hard and soft tissue healing strategies. However, more research is needed for defining GT applicability in the future of biomedical engineering. On this object, the present review aims to provide a state-of-the-art overview of GT in biomedicine and tries to open new horizons in the field based on its inherent characteristics.
天然存在的材料在生物医学中的应用越来越引起研究人员的兴趣，在这方面，刺梧桐树胶（GT）最近作为组织工程和再生医学中的治疗物质显示出巨大的潜力。作为一种多糖，GT 可以很容易地从各种刺梧桐树的茎和枝中提取。这种阴离子聚合物是一种可生物降解、无过敏原、无毒、无致癌的物质。GT 对微生物、热和酸降解的稳定性使其不仅在工业环境（如食品包装）中，而且在生物医学方法（如药物输送）中成为一种有吸引力的材料。随着时间的推移，GT 已被证明是在绿色化学背景下形成和稳定金属纳米粒子的有用试剂。随着组织工程的出现，GT 也被用于制造用于硬组织和软组织修复策略的三维（3D）支架。然而，为了在未来的生物医学工程中确定 GT 的适用性，还需要进行更多的研究。在这个对象上，本综述旨在提供 GT 在生物医学中的最新概述，并尝试基于其固有特性在该领域开辟新的视野。
