Department of Emergency and Critical Care Medicine, Hitachi General Hospital, Hitachi, Ibaraki 317-0077, Japan.
Department of Emergency and Critical Care Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Nutrients. 2021 Mar 10;13(3):899. doi: 10.3390/nu13030899.
The effects of beta-hydroxy-beta-methylbutyrate (HMB) complex administration and the significance of titin, a biomarker of muscle injury, in elderly minor trauma patients in acute phase has not been established. In this single-center, randomized controlled study, trauma patients aged ≥ 70 years with an injury severity score < 16 were included. Titin values on days 1 and 3 were measured and the intervention group received HMB complex (2.4 g of HMB + 14 g of glutamine + 14 g of arginine) and the control group received glutamine complex (7.2 g of protein including 6 g of glutamine). The cross-sectional area of the rectus femoris (RFCSA) on ultrasound, grip strength, and the Barthel Index were assessed on the first day of rehabilitation and after 2 weeks. We analyzed 24 HMB and 25 control participants. Titin values on day 3 correlated with grip strength ( = -0.34, = 0.03) and the Barthel Index ( = -0.39, = 0.01) at follow-up. HMB complex supplementation had no effect on the RFCSA (2.41 vs. 2.45 cm, = 0.887), grip strength (13.3 vs. 13.1 kg, = 0.946), or the Barthel Index (20.0 vs. 50.0, = 0.404) at follow-up. Titin values might associate with subsequent physical function. Short-term HMB complex supplementation from acute phase did not ameliorate muscle injury.
β-羟-β-甲基丁酸（HMB）复合物的作用以及肌钙蛋白（肌肉损伤的生物标志物）在急性老年小创伤患者中的意义尚未确定。在这项单中心、随机对照研究中，纳入了年龄≥70 岁、损伤严重程度评分<16 的创伤患者。测量了第 1 天和第 3 天的肌钙蛋白值，干预组接受 HMB 复合物（2.4 g HMB+14 g 谷氨酰胺+14 g 精氨酸），对照组接受谷氨酰胺复合物（7.2 g 蛋白质，其中包括 6 g 谷氨酰胺）。在康复的第一天和 2 周后，通过超声评估股直肌（RFCSA）的横截面积、握力和巴氏指数。我们分析了 24 名 HMB 和 25 名对照组参与者。第 3 天的肌钙蛋白值与握力（=-0.34，=0.03）和随访时的巴氏指数（=-0.39，=0.01）相关。HMB 复合物补充剂对 RFCSA（2.41 对 2.45 cm，=0.887）、握力（13.3 对 13.1 kg，=0.946）或随访时的巴氏指数（20.0 对 50.0，=0.404）没有影响。肌钙蛋白值可能与随后的身体功能有关。从急性期开始短期 HMB 复合物补充并不能改善肌肉损伤。
