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[一种在动物实验中制造梗阻性脑积水的新模型]

[A new model for producing occlusive hydrocephalus in animal experiments].

作者信息

Krähling K H, König H J, Anagnostopoulos-Schleep J

机构信息

Neurochirurgische Universitätsklinik Münster.

出版信息

Neurochirurgia (Stuttg). 1988 Mar;31(2):54-7. doi: 10.1055/s-2008-1053901.

Abstract

Production of hydrocephalus in animal experiment has been difficult and not uniformly successful so far. The preparation Ethibloc (supplied by Ethicon, Hamburg-Norderstedt), which is a protein solution in alcohol, and which has been in use in abdominal surgery for occluding the pancreatic duct system, enables production of an obstructive hydrocephalus easily and with reproducible results. The authors report on 24 cases of development of an obstructive hydrocephalus in rabbits after Ethibloc had been introduced into the ventricular system.

摘要

迄今为止,在动物实验中制造脑积水一直很困难,而且成功率并不一致。Ethibloc制剂(由位于汉堡-北德施泰特的Ethicon公司提供)是一种酒精中的蛋白质溶液,已用于腹部手术中阻塞胰管系统,它能够轻松制造出梗阻性脑积水,且结果具有可重复性。作者报告了在将Ethibloc引入脑室系统后,24只兔子发生梗阻性脑积水的病例。

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