Molecular Oncology Research Center, Barretos Cancer Hospital, Teaching and Research Institute, Barretos-SP 14784-400, Brazil.
Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo-SP 01246-000, Brazil.
Cells. 2021 Mar 17;10(3):668. doi: 10.3390/cells10030668.
To obtain a better understanding on the role of microRNAs in the progression of cervical cancer, a systematic review was performed to analyze cervical cancer microRNA studies. We provide an overview of the studies investigating microRNA expression in relation to cervical cancer (CC) progression, highlighting their common outcomes and target gene interactions according to the regulatory pathways. To achieve this, we systematically searched through PubMed MEDLINE, EMBASE, and Google Scholar for all articles between April 2010 and April 2020, in accordance with the PICO acronym (participants, interventions, comparisons, outcomes). From 27 published reports, totaling 1721 cases and 1361 noncancerous control tissue samples, 26 differentially expressed microRNAs (DEmiRNAs) were identified in different International Federation of Gynecology and Obstetrics (FIGO) stages of cervical cancer development. It was identified that some of the dysregulated microRNAs were associated with specific stages of cervical cancer development. The results indicated that DEmiRNAs in different stages of cervical cancer were functionally involved in several key hallmarks of cancer, such as evading growth suppressors, enabling replicative immortality, activation of invasion and metastasis, resisting cell death, and sustained proliferative signaling. These dysregulated microRNAs could play an important role in cervical cancer's development. Some of the stage-specific microRNAs can also be used as biomarkers for cancer classification and monitoring the progression of cervical cancer.
为了更好地了解 microRNAs 在宫颈癌进展中的作用，我们进行了一项系统综述，以分析宫颈癌 microRNA 研究。我们提供了一项关于研究 microRNA 表达与宫颈癌（CC）进展之间关系的综述，根据调控途径突出了它们的常见结果和靶基因相互作用。为了实现这一目标，我们按照 PICO 缩写（参与者、干预措施、比较、结果），系统地搜索了 PubMed MEDLINE、EMBASE 和 Google Scholar 中的所有文章，时间范围为 2010 年 4 月至 2020 年 4 月。从 27 篇已发表的报告中，总计 1721 例病例和 1361 例非癌性对照组织样本中，鉴定出 26 个在不同国际妇产科联合会（FIGO）宫颈癌发展阶段存在差异表达的 microRNAs（DEmiRNAs）。研究发现，一些失调的 microRNAs 与宫颈癌发展的特定阶段有关。结果表明，不同阶段宫颈癌中的 DEmiRNAs 在几个癌症关键特征的功能上存在相关性，如逃避生长抑制物、实现复制永生、激活侵袭和转移、抵抗细胞死亡和持续增殖信号。这些失调的 microRNAs 可能在宫颈癌的发展中发挥重要作用。一些特定于阶段的 microRNAs 也可以用作癌症分类的生物标志物，并监测宫颈癌的进展。
