García Inés, Trobajo Camino, Amghouz Zakariae, Adawy Alaa
Nanomaterials and Nanotechnology Research Centre-CINN (CSIC), 33940 El Entrego, Spain.
Department of Organic and Inorganic Chemistry, University of Oviedo, 33006 Oviedo, Spain.
Materials (Basel). 2021 Mar 18;14(6):1481. doi: 10.3390/ma14061481.
There is an increasing demand on synthesizing pharmaceuticals and biomaterials that possess antimicrobial and/or antiviral activities. In this respective silver nanoparticles are known for their excellent antimicrobial activity. Nevertheless, their uncontrolled release in a biological medium can induce a cytotoxic effect. For this, we explored the use of nanolayered metal phosphates based on titanium and zirconium as materials that can be enriched with silver nanoparticles. Employing the hydrothermal route, crystalline α-phases of zirconium and titanium phosphates (α-ZrP, α-TiP) were synthesized and there after surface-enriched with silver nanoparticles. The structural assessment confirmed the stability of the structures and their sizes are in the nanoscale at least in one dimension. The cytocompatibility assays confirmed the biocompatibility of the pristine phases and the antimicrobial assay confirmed that both silver-enriched nanolayered structures maintain an antibacterial effect at reasonably low concentrations.
合成具有抗菌和/或抗病毒活性的药物和生物材料的需求日益增加。在这方面，银纳米颗粒以其出色的抗菌活性而闻名。然而，它们在生物介质中的不受控制的释放会诱导细胞毒性作用。为此，我们探索了使用基于钛和锆的纳米层状金属磷酸盐作为可以富集银纳米颗粒的材料。采用水热法合成了锆和钛磷酸盐的结晶α相（α-ZrP、α-TiP），然后在其表面富集银纳米颗粒。结构评估证实了结构的稳定性，并且它们的尺寸至少在一个维度上处于纳米尺度。细胞相容性测定证实了原始相的生物相容性，抗菌测定证实了两种富含银的纳米层状结构在相当低的浓度下都保持抗菌效果。
