Peng Tzu-Yu, Lin Dan-Jae, Mine Yuichi, Tasi Chi-Yang, Li Po-Jung, Shih Yin-Hwa, Chiu Kuo-Chou, Wang Tong-Hong, Hsia Shih-Min, Shieh Tzong-Ming
School of Dentistry, College of Dentistry, China Medical University, Taichung 40402, Taiwan.
Department of Medical System Engineering, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima City, Hiroshima 734-8553, Japan.
Polymers (Basel). 2021 Mar 18;13(6):940. doi: 10.3390/polym13060940.
Poly-ether-ether-ketone (PEEK) is an aesthetically pleasing natural material with good biocompatibility and shock absorption characteristics. The application of PEEK as a dental implant or abutment is expected to reduce the risk of failure and enhance aesthetics. Given that approximately one in 15 patients have allergic reactions to antibiotics, photodynamic therapy (PDT) has been gaining attention as an alternative treatment. Herein, the applicability of PEEK dental implants or abutments was investigated using material analyses, biofilm formation assay, and cell viability tests. The possible use of PDT for peri-implant mucositis was evaluated with the biofilm removal assay. The obtained data were analyzed based on the multivariate analysis of variance, paired t-tests, and the Pearson correlation coefficient (α = 0.05). The results revealed that PEEK was significantly less conducive to the formation of biofilms with and < 0.001) but exhibited comparable MG-63 (human osteoblast-like) osteoblast cell viability ( > 0.05) to the other materials. PDT had similar antimicrobial efficacy and yielded similar biofilm removal effects to antibiotics. Altogether, these findings suggest that PEEK has attractive features and can serve as an alternative material for dental implants or abutments. In cases where peri-implant mucositis occurs, PDT can be used as an accessible therapeutic approach.
聚醚醚酮（PEEK）是一种美观的天然材料，具有良好的生物相容性和减震特性。将PEEK用作牙种植体或基台有望降低失败风险并提升美观度。鉴于约每15名患者中有1人对抗生素有过敏反应，光动力疗法（PDT）作为一种替代治疗方法正受到关注。在此，通过材料分析、生物膜形成测定和细胞活力测试，研究了PEEK牙种植体或基台的适用性。通过生物膜去除测定评估了PDT用于种植体周围黏膜炎的可能性。基于多变量方差分析、配对t检验和皮尔逊相关系数（α = 0.05）对获得的数据进行了分析。结果显示，PEEK显著不利于生物膜形成（< 0.001），但与其他材料相比，MG-63（人成骨样）成骨细胞活力相当（> 0.05）。PDT具有与抗生素相似的抗菌功效和生物膜去除效果。总之，这些发现表明PEEK具有吸引人的特性，可作为牙种植体或基台的替代材料。在发生种植体周围黏膜炎的情况下，PDT可作为一种可行的治疗方法。
