通过快速纳米沉淀法制备的具有高载药量的经济高效纳米姜黄素递送系统。

A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation.

作者信息

Chen Zhuo, Fu Zhinan, Li Li, Ma Enguang, Guo Xuhong

机构信息

State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China.

Engineering Research Center of Materials Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Shihezi 832000, China.

出版信息

Nanomaterials (Basel). 2021 Mar 15;11(3):734. doi: 10.3390/nano11030734.

Flash nanoprecipitation (FNP) is an efficient technique for encapsulating drugs in particulate carriers assembled by amphiphilic polymers. In this study, a novel nanoparticular system of a model drug curcumin (CUR) based on FNP technique was developed by using cheap and commercially available amphiphilic poly(vinyl pyrrolidone) (PVP) as stabilizer and natural polymer chitosan (CS) as trapping agent. Using this strategy, high encapsulation efficiency (EE > 95%) and drug loading capacity (DLC > 40%) of CUR were achieved. The resulting CUR-loaded nanoparticles (NPs) showed a long-term stability (at least 2 months) and pH-responsive release behavior. This work offers a new strategy to prepare cost-effective drug-loaded NPs with high drug loading capacity and opens a unique opportunity for industrial scale-up.

快速纳米沉淀法（FNP）是一种将药物包裹于两亲性聚合物组装而成的颗粒载体中的有效技术。在本研究中，以廉价且市售的两亲性聚乙烯吡咯烷酮（PVP）为稳定剂、天然聚合物壳聚糖（CS）为捕获剂，基于FNP技术开发了一种新型的模型药物姜黄素（CUR）纳米颗粒系统。采用该策略，实现了姜黄素的高包封率（EE > 95%）和载药量（DLC > 40%）。所得载姜黄素纳米颗粒（NPs）表现出长期稳定性（至少2个月）和pH响应释放行为。这项工作为制备具有高载药量的经济高效载药纳米颗粒提供了一种新策略，并为工业放大生产提供了独特机遇。