Institute of Nuclear Physics Polish Academy of Sciences, 31-342 Krakow, Poland.
Department of Endocrinology, Nuclear Medicine Unit, The University Hospital, 31-501 Krakow, Poland.
Int J Mol Sci. 2020 Nov 29;21(23):9082. doi: 10.3390/ijms21239082.
Herein, we propose newly designed and synthesized gold nanopeanuts (Au NPes) as supports for cisplatin (cPt) immobilization, dedicated to combined glioblastoma nano-chemo-radiotherapy. Au NPes offer a large active surface, which can be used for drugs immobilization. Transmission electron microscopy (TEM) revealed that the size of the synthesized Au NPes along the longitudinal axis is ~60 nm, while along the transverse axis ~20 nm. Raman, thermogravimetric analysis (TGA) and differential scanning calorimetry (DCS) measurements showed, that the created nanosystem is stable up to a temperature of 110 °C. MTT assay revealed, that the highest cell mortality was observed for cell lines subjected to nano-chemo-radiotherapy (20-55%). Hence, Au NPes with immobilized cPt (cPt@AuNPes) are a promising nanosystem to improve the therapeutic efficiency of combined nano-chemo-radiotherapy.
在此，我们提出了新设计和合成的金纳米花生（Au NPes）作为顺铂（cPt）固定的载体，专门用于胶质母细胞瘤的纳米化联合化疗和放疗。Au NPes 提供了一个很大的活性表面，可用于药物固定。透射电子显微镜（TEM）显示，合成的 Au NPes 沿纵向轴的尺寸约为 60nm，而沿横向轴的尺寸约为 20nm。拉曼、热重分析（TGA）和差示扫描量热法（DCS）测量表明，所创建的纳米系统在 110°C 的温度下是稳定的。MTT 试验表明，在接受纳米化联合化疗和放疗的细胞系中观察到最高的细胞死亡率（20-55%）。因此，固定有 cPt 的 Au NPes（cPt@AuNPes）是一种很有前途的纳米系统，可提高联合纳米化化疗和放疗的治疗效果。
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