Maximenko Alexey, Depciuch Joanna, Łopuszyńska Natalia, Stec Malgorzata, Światkowska-Warkocka Żaneta, Bayev Vadim, Zieliński Piotr M, Baran Jaroslaw, Fedotova Julia, Węglarz Władysław P, Parlinska-Wojtan Magdalena
Institute of Nuclear Physics Polish Academy of Sciences Radzikowskiego 152 31-342 Kraków Poland
Research Institute for Nuclear Problems of Belarusian State University Bobruyskaya 11 220030 Minsk Belarus.
RSC Adv. 2020 Jul 15;10(44):26508-26520. doi: 10.1039/d0ra03699d. eCollection 2020 Jul 9.
Novel functionalized (biofunctionalization followed by cisplatin immobilization) FeO@SiO@Au nanoparticles (NPs) were designed. The encapsulation of FeO cores inside continuous SiO shells preserves their initial structure and strong magnetic properties, while the shell surface can be decorated by small Au NPs, and then cisplatin (cPt) can be successfully immobilized on their surface. The fabricated NPs exhibit very strong contrasting properties for magnetic resonance imaging (MRI). The functionalized FeO@SiO@Au NPs are tested for a potential application in photothermal cancer therapy, which is simulated by irradiation of two colon cancer cell lines (SW480 and SW620) with a laser ( = 808 nm, = 100 mW cm). It is found that the functionalized NPs possess low toxicity towards cancer cells (∼10-15%), which however could be drastically increased by laser irradiation, leading to a mortality of the cells of ∼43-50%. This increase of the cytotoxic properties of the FeO@SiO@Au NPs, due to the synergic effect between the presence of cPt plus Au NPs and laser irradiation, makes these NPs perspective agents for potential (MRI)-guided stimulated chemo-photothermal treatment of cancer.
设计了新型功能化（生物功能化后固定顺铂）的FeO@SiO@Au纳米颗粒（NPs）。将FeO核包裹在连续的SiO壳内可保留其初始结构和强磁性，而壳表面可用小的Au NPs进行修饰，然后顺铂（cPt）可成功固定在其表面。制备的NPs在磁共振成像（MRI）中表现出非常强的对比特性。对功能化的FeO@SiO@Au NPs进行了光热癌症治疗的潜在应用测试，通过用激光（ = 808 nm， = 100 mW cm）照射两种结肠癌细胞系（SW480和SW620）来模拟。发现功能化的NPs对癌细胞具有低毒性（约10 - 15%），然而通过激光照射毒性可大幅增加，导致细胞死亡率约为43 - 50%。由于cPt加Au NPs的存在与激光照射之间的协同作用，FeO@SiO@Au NPs细胞毒性特性的这种增加，使这些NPs成为潜在的用于（MRI）引导的癌症刺激化学光热治疗的有前景的药物。
