Ornello Raffaele, Frattale Ilaria, Caponnetto Valeria, De Matteis Eleonora, Pistoia Francesca, Sacco Simona
Neuroscience Section, Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, 67100 L'Aquila, Italy.
Child Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University, 00133 Rome, Italy.
Brain Sci. 2021 Mar 13;11(3):370. doi: 10.3390/brainsci11030370.
We aimed to assess the differences between menstrual and non-menstrual headache in women with chronic migraine treated with erenumab.
We included fertile women from a single center. Patients were defined as responders to erenumab if reporting a ≥50% decrease in monthly headache days, as compared to pre-treatment for more than half of the treatment period. Premenstrual days were defined as the two days preceding menstruation, while menstrual days were defined as the first three days of menstruation.
We included 18 women (11 erenumab responders and 7 erenumab non-responders) contributing to a total of 103 menstrual cycles and 2926 days. The proportion of headache days was higher in menstrual than in premenstrual and non-menstrual days in erenumab responders (34.4% vs. 14.8% vs. 16.3%, respectively; < 0.001) and in erenumab non-responders (71.4% vs. 53.6% vs. 48.3%, respectively; < 0.001). Headache days with ≥2 acute medications were higher in menstrual than in premenstrual or non-menstrual headache days in erenumab non-responders ( = 0.002) but not in erenumab responders ( = 0.620).
Our data suggest that migraine is more frequent during than outside menstrual days even in women treated with erenumab.
我们旨在评估接受erenumab治疗的慢性偏头痛女性月经性头痛和非月经性头痛之间的差异。
我们纳入了来自单一中心的育龄女性。如果患者报告在超过一半的治疗期内每月头痛天数较治疗前减少≥50%，则被定义为erenumab应答者。经前期被定义为月经前的两天，而月经期被定义为月经的前三天。
我们纳入了18名女性（11名erenumab应答者和7名erenumab无应答者），共涉及103个月经周期和2926天。在erenumab应答者中，月经期的头痛天数比例高于经前期和非月经期（分别为34.4%、14.8%和16.3%；<0.001），在erenumab无应答者中也是如此（分别为71.4%、53.6%和48.3%；<0.001）。在erenumab无应答者中，使用≥2种急性药物的头痛天数在月经期高于经前期或非月经期（P=0.002），但在erenumab应答者中并非如此（P=0.620）。
我们的数据表明，即使在接受erenumab治疗的女性中，偏头痛在月经期比非月经期更频繁。
