Casin Kevin M, Calvert John W
Carlyle Fraser Heart Center, Division of Cardiothoracic Surgery, Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
Antioxidants (Basel). 2021 Mar 4;10(3):383. doi: 10.3390/antiox10030383.
Cardiovascular disease is the leading cause of death in the U.S. While various studies have shown the beneficial impact of exogenous hydrogen sulfide (HS)-releasing drugs, few have demonstrated the influence of endogenous HS production. Modulating the predominant enzymatic sources of HS-cystathionine-β-synthase, cystathionine-γ-lyase, and 3-mercaptopyruvate sulfurtransferase-is an emerging and promising research area. This review frames the discussion of harnessing endogenous HS within the context of a non-ischemic form of cardiomyopathy, termed diabetic cardiomyopathy, and heart failure. Also, we examine the current literature around therapeutic interventions, such as intermittent fasting and exercise, that stimulate HS production.
心血管疾病是美国的主要死因。虽然各种研究已经表明外源性硫化氢（HS）释放药物的有益影响，但很少有研究证明内源性HS产生的影响。调节HS的主要酶源——胱硫醚-β-合酶、胱硫醚-γ-裂解酶和3-巯基丙酮酸硫转移酶——是一个新兴且有前景的研究领域。本综述在一种非缺血性心肌病（称为糖尿病性心肌病）和心力衰竭的背景下，对利用内源性HS进行了讨论。此外，我们还研究了围绕间歇性禁食和运动等刺激HS产生的治疗干预措施的现有文献。
