从青年到成年的身体活动不足与成年人心血管代谢风险特征。
Physical inactivity from youth to adulthood and adult cardiometabolic risk profile.
机构信息
Paavo Nurmi Centre & Unit for Health and Physical Activity, University of Turku, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Paavo Nurmi Centre & Unit for Health and Physical Activity, University of Turku, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
出版信息
Prev Med. 2021 Apr;145:106433. doi: 10.1016/j.ypmed.2021.106433. Epub 2021 Jan 23.
Adults with a low physical activity (PA) level are at increased risk for cardiometabolic diseases, but little is known on the association between physical inactivity since youth and cardiometabolic health in adulthood. We investigated the association of persistent physical inactivity from youth to adulthood with adult cardiometabolic risk factors. Data were drawn from the ongoing Cardiovascular Risk in Young Finns Study with seven follow-ups between 1980 and 2011 (baseline age 3-18 years, n = 1961). Physical activity data from a standardized questionnaire was expressed as a PA-index. Using the PA-index, four groups were formed: 1)persistently physically inactive (n = 246), 2)decreasingly active (n = 305), 3)increasingly active (n = 328), and 4)persistently active individuals (n = 1082). Adulthood cardiometabolic risk indicators included waist circumference, body mass index (BMI), blood pressure, and fasting lipids, insulin, and glucose. Clustered cardiometabolic risk was defined using established criteria for metabolic syndrome. Persistently physically inactive group was used as a reference. Compared to the persistently physically inactive group, those who were persistently active had lower risk for adult clustered cardiometabolic risk (RR = 0.67;CI95% = 0.53-0.84; Harmonized criteria), obesity (BMI > 30 kg/m, RR = 0.76;CI95% = 0.59-0.98), high waist circumference (RR = 0.82;CI95% = 0.69-0.98), and high triglyceride (RR = 0.60;CI95% = 0.47-0.75), insulin (RR = 0.58;CI95% = 0.46-0.74) and glucose (RR = 0.77;CI95% = 0.62-0.96) concentrations as well as low high-density lipoprotein cholesterol (HDLC) concentration (RR = 0.78;CI95% = 0.66-0.93). Comparable results were found when persistently physically inactive individuals were compared with those who increased PA. The results remained essentially similar after adjustment for education, diet, smoking, and BMI. Persistently physically inactive lifestyle since youth is associated with an unfavorable cardiometabolic risk profile in adulthood. Importantly, even minor increase in PA lowers the cardiometabolic risk.
成年人身体活动（PA）水平较低，患心血管代谢疾病的风险增加，但对于青少年时期身体不活动与成年后心血管代谢健康之间的关系知之甚少。我们研究了从青少年时期到成年期持续不活动与成年人心血管代谢危险因素之间的关系。数据来自于正在进行的芬兰年轻人心血管风险研究，该研究在 1980 年至 2011 年期间进行了七次随访（基线年龄 3-18 岁，n=1961）。来自标准化问卷的身体活动数据表示为 PA 指数。使用 PA 指数，将四个组分为：1）持续不活跃（n=246），2）逐渐不活跃（n=305），3）逐渐活跃（n=328），4）持续活跃个体（n=1082）。成年人心血管代谢风险指标包括腰围、体重指数（BMI）、血压和空腹血脂、胰岛素和血糖。代谢综合征的既定标准定义了聚集的心血管代谢风险。以持续不活跃组作为参考。与持续不活跃组相比，持续活跃组的成年人心血管代谢风险聚集（RR=0.67；95%CI95%=0.53-0.84；协调标准）、肥胖（BMI>30kg/m，RR=0.76；95%CI95%=0.59-0.98）、高腰围（RR=0.82；95%CI95%=0.69-0.98）和高甘油三酯（RR=0.60；95%CI95%=0.47-0.75）、胰岛素（RR=0.58；95%CI95%=0.46-0.74）和葡萄糖（RR=0.77；95%CI95%=0.62-0.96）浓度以及低高密度脂蛋白胆固醇（HDLC）浓度（RR=0.78；95%CI95%=0.66-0.93）的风险较低。当将持续不活跃的个体与增加 PA 的个体进行比较时，也得到了类似的结果。调整教育、饮食、吸烟和 BMI 后，结果基本保持不变。青少年时期持续不活跃的生活方式与成年后不利的心血管代谢风险特征相关。重要的是，即使 PA 略有增加，也能降低心血管代谢风险。
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