Inchingolo Angelo Michele, Inchingolo Alessio Danilo, Nardelli Paola, Latini Giulia, Trilli Irma, Ferrante Laura, Malcangi Giuseppina, Palermo Andrea, Inchingolo Francesco, Dipalma Gianna
Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
College of Medicine and Dentistry, Birmingham B4 6BN, UK.
J Funct Biomater. 2024 Oct 15;15(10):308. doi: 10.3390/jfb15100308.
Regenerative medicine in dentistry focuses on repairing damaged oral tissues using advanced tools like stem cells, biomaterials, and tissue engineering (TE). Mesenchymal stem cells (MSCs) from dental sources, such as dental pulp and periodontal ligament, show significant potential for tissue regeneration due to their proliferative and differentiative abilities. This systematic review, following PRISMA guidelines, evaluated fifteen studies and identified effective strategies for improving dental, periodontal, and bone tissue regeneration through scaffolds, secretomes, and bioengineering methods. Key advancements include the use of dental pulp stem cells (DPSCs) and periodontal ligament stem cells (PDLSCs) to boost cell viability and manage inflammation. Additionally, pharmacological agents like matrine and surface modifications on biomaterials improve stem cell adhesion and promote osteogenic differentiation. By integrating these approaches, regenerative medicine and TE can optimize dental therapies and enhance patient outcomes. This review highlights the potential and challenges in this field, providing a critical assessment of current research and future directions.
牙科再生医学专注于使用干细胞、生物材料和组织工程（TE）等先进工具修复受损的口腔组织。来自牙髓和牙周韧带等牙科来源的间充质干细胞（MSCs），由于其增殖和分化能力，在组织再生方面显示出巨大潜力。本系统评价遵循PRISMA指南，评估了15项研究，并确定了通过支架、分泌组和生物工程方法改善牙齿、牙周和骨组织再生的有效策略。关键进展包括使用牙髓干细胞（DPSCs）和牙周韧带干细胞（PDLSCs）来提高细胞活力和控制炎症。此外，苦参碱等药物制剂和生物材料的表面修饰可改善干细胞黏附并促进成骨分化。通过整合这些方法，再生医学和组织工程可以优化牙科治疗并改善患者预后。本综述强调了该领域的潜力和挑战，对当前研究和未来方向进行了批判性评估。
