Norbäck Dan, Wieslander Gunilla
Department of Medical Science, Uppsala University, SE 75185 Uppsala, Sweden.
Plants (Basel). 2021 Mar 23;10(3):607. doi: 10.3390/plants10030607.
Cultivated buckwheat include two species originating from China: common buckwheat () and tartary buckwheat (). Buckwheat can cause IgE-mediated allergy, including severe allergic reactions and anaphylaxis. Exposure can occure when eating buckwheat food (food allergen), when producing or handling buckwheat food (occupational exposure) or when sleeping on buckwheat husk pillows (houeshold environmental exposure).
A search on buckwheat allergy in the medical datbase PubMed from 1970-2020.
A number of allergenic proteins have been identified in common buckwheat (e.g., Fag e 1, Fag e 2 and Fag e 3) and in tartary buckwheat (e.g., Fag t 1, Fag t 2, Fag t 3). Clinically relevant cross-reactivity has been described between buckwheat and peanut, latex, coconut, quinoa, and poppy seed. The prevalence of buckwheat allergy in the population can be estimated as 0.1-0.4% in Japan, Korea and buckwheat consuming areas of China. Among patients in allergy clinics in different countries, 2-7% has confirmed buckwheat allergy. School studies from Japan and Korea found 4-60 cases of buckwheat-related anaphylaxis per 100,000 school children. The incidence of severe allergic reactions to buckwheat, including anaphylaxis, can be estimated as 0.1-0.01 cases per 100,000 person-years.
Buckwheat allergy is a neglected allegy deserving further attention but severe allergic reactions are rare.
栽培荞麦包括两个原产于中国的物种：普通荞麦（ ）和苦荞麦（ ）。荞麦可引起IgE介导的过敏反应，包括严重过敏反应和过敏症。食用荞麦食品（食物过敏原）、生产或处理荞麦食品（职业暴露）或使用荞麦壳枕头睡眠（家庭环境暴露）时都可能发生接触。
在医学数据库PubMed中检索1970年至2020年期间关于荞麦过敏的文献。
已在普通荞麦（如Fag e 1、Fag e 2和Fag e 3）和苦荞麦（如Fag t 1、Fag t 2、Fag t 3）中鉴定出多种致敏蛋白。已报道荞麦与花生、乳胶、椰子、藜麦和罂粟籽之间存在临床相关的交叉反应。在日本、韩国和中国的荞麦消费地区，人群中荞麦过敏的患病率估计为0.1%-0.4%。在不同国家的过敏诊所患者中，2%-7%已确诊为荞麦过敏。日本和韩国的学校研究发现，每10万名学童中有4-60例与荞麦相关的过敏症。对荞麦的严重过敏反应（包括过敏症）的发病率估计为每10万人年0.1-0.01例。
荞麦过敏是一种被忽视的过敏症，值得进一步关注，但严重过敏反应很少见。
