含二异丙基硅基核苷酸间连接键的六核苷酸类似物的合成。
Synthesis of hexanucleotide analogues containing diisopropylsilyl internucleotide linkages.
作者信息
Cormier J F, Ogilvie K K
机构信息
Department of Chemistry, McGill University, Montreal, Quebec, Canada.
出版信息
Nucleic Acids Res. 1988 May 25;16(10):4583-94. doi: 10.1093/nar/16.10.4583.
Abstract
The synthesis of two silyl-linked hexanucleotide analogues is described. Hypochromicity and CD measurements indicate that the thymidine hexanucleotide analogue bears a strong resemblance to its phosphodiester-linked counterpart.
摘要
本文描述了两种硅烷基连接的六核苷酸类似物的合成。减色效应和圆二色性测量表明，胸腺嘧啶六核苷酸类似物与其磷酸二酯连接的对应物非常相似。
相似文献
1
Synthesis of hexanucleotide analogues containing diisopropylsilyl internucleotide linkages.含二异丙基硅基核苷酸间连接键的六核苷酸类似物的合成。
Nucleic Acids Res. 1988 May 25;16(10):4583-94. doi: 10.1093/nar/16.10.4583.
2
Novel method of the synthesis and hybridization properties of an oligonucleotide containing non-ionic diisopropylsilyl internucleotide linkage.一种含有非离子二异丙基硅烷核苷酸键的寡核苷酸的合成和杂交性质的新方法。
Bioorg Med Chem. 2013 Dec 15;21(24):8013-8. doi: 10.1016/j.bmc.2013.08.058. Epub 2013 Sep 6.
3
Synthesis and physical characterization of the self-complementary, alternating pyrimidine/purine hexanucleotide d[CGTACG].自我互补交替嘧啶/嘌呤六核苷酸d[CGTACG]的合成与物理表征
Nucleic Acids Res. 1982 Oct 25;10(20):6265-71. doi: 10.1093/nar/10.20.6265.
4
5
The influence of the purine 2-amino group on DNA conformation and stability. Synthesis and conformational analysis of d[T(2-aminoA)]3.嘌呤2-氨基对DNA构象和稳定性的影响。d[T(2-氨基A)]3的合成与构象分析。
Nucleic Acids Res. 1982 Jul 24;10(14):4351-61. doi: 10.1093/nar/10.14.4351.
6
Synthesis and properties of a new oligonucleotide analogue containing an internucleotide squaryl amide linkage.
Nucleic Acids Res Suppl. 2001(1):121-2. doi: 10.1093/nass/1.1.121.
7
8
Stereoselective synthesis of P-homochiral oligo(thymidine methanephosphonates).P-同手性寡聚（胸苷甲膦酸酯）的立体选择性合成。
Nucleic Acids Res. 1988 Dec 23;16(24):11675-89. doi: 10.1093/nar/16.24.11675.
9
Synthesis and properties of 5'-triphosphoryl 2'-5' oligoadenylates (2-5A), and a general method for synthesis of 3', 5'-bisphosphorylated oligonucleotides.5'-三磷酸化2'-5'寡腺苷酸（2-5A）的合成与性质，以及3',5'-双磷酸化寡核苷酸的通用合成方法。
Nucleic Acids Res. 1981 Apr 24;9(8):2003-20. doi: 10.1093/nar/9.8.2003.
10
Specifically alkylated DNA fragments. Synthesis and physical characterization of d[CGC(O6Me)GCG] and d[CGT(O6Me)GCG].特定烷基化的DNA片段。d[CGC(O6Me)GCG]和d[CGT(O6Me)GCG]的合成及物理特性表征
Nucleic Acids Res. 1983 May 25;11(10):3393-403. doi: 10.1093/nar/11.10.3393.
引用本文的文献
1
Fluoride-cleavable biotinylation phosphoramidite for 5'-end-labeling and affinity purification of synthetic oligonucleotides.用于合成寡核苷酸5'端标记和亲和纯化的氟化物可裂解生物素化亚磷酰胺。
Nucleic Acids Res. 2003 Jan 15;31(2):708-15. doi: 10.1093/nar/gkg130.
2
Solid-phase synthesis and hybridization properties of DNA containing sulfide-linked dinucleosides.含硫醚连接二核苷的DNA的固相合成及杂交性质
Nucleic Acids Res. 1993 Mar 25;21(6):1473-9. doi: 10.1093/nar/21.6.1473.
3
Oligoribonucleotides containing 2',5'-phosphodiester linkages exhibit binding selectivity for 3',5'-RNA over 3',5'-ssDNA.含有2',5'-磷酸二酯键的寡核糖核苷酸对3',5'-RNA的结合选择性高于3',5'-单链DNA。
Nucleic Acids Res. 1993 Oct 11;21(20):4742-9. doi: 10.1093/nar/21.20.4742.
4
Approaches to antiviral drug development.抗病毒药物研发方法。
Yale J Biol Med. 1989 Mar-Apr;62(2):215-25.
5
Sequence dependent effects in methylphosphonate deoxyribonucleotide double and triple helical complexes.甲基膦酸酯脱氧核糖核苷酸双链和三链螺旋复合物中的序列依赖性效应。
Nucleic Acids Res. 1990 Jun 25;18(12):3545-55. doi: 10.1093/nar/18.12.3545.
本文引用的文献
1
Phosphoramidate analogs of oligonucleotides.寡核苷酸的磷酰胺酯类似物。
J Org Chem. 1970 Nov;35(11):3800-3. doi: 10.1021/jo00836a048.
2
Synthesis of carbonate analogs of dinucleosides. 3'-Thymidinyl 5'-thymidinyl carbonate, 3'-thymidinyl 5'-(5-fluoro-2'-deoxyuridinyl) carbonate, and 3'-(5-fluoro-2'-deoxyuridinyl) 5'-thymidinyl carbonate.
J Med Chem. 1969 Jan;12(1):154-7. doi: 10.1021/jm00301a041.
3
Synthesis of cyclic silyl nucleosides having bulky groups on the silicon atom.在硅原子上带有庞大基团的环状甲硅烷基核苷的合成。
Nucleic Acids Symp Ser. 1985(16):85-7.
4
Carbamate analogues of oligonucleotides.寡核苷酸的氨基甲酸酯类似物。
J Org Chem. 1977 Feb 18;42(4):703-6. doi: 10.1021/jo00424a028.
5
Nonionic nucleic acid analogues. Synthesis and characterization of dideoxyribonucleoside methylphosphonates.
Biochemistry. 1979 Nov 13;18(23):5134-43. doi: 10.1021/bi00590a017.
6
Synthesis and enzymatic properties of deoxyribooligonucleotides containing methyl and phenylphosphonate linkages.含甲基和苯基膦酸酯键的脱氧核糖寡核苷酸的合成及酶学性质
Nucleic Acids Res. 1979 Jul 11;6(9):3009-24. doi: 10.1093/nar/6.9.3009.
Zotero 插件