吡咯里西啶生物碱在药理学应用中的现有知识和观点：综述。
Current Knowledge and Perspectives of Pyrrolizidine Alkaloids in Pharmacological Applications: A Mini-Review.
机构信息
Institute of Entomology, College of Life Sciences, Nankai University, Tianjin 300071, China.
Plant Science and Natural Products, Institute of Biology, Leiden University, Sylviusweg 72, P.O. Box 9505, 2300 RA Leiden, The Netherlands.
出版信息
Molecules. 2021 Mar 31;26(7):1970. doi: 10.3390/molecules26071970.
Pyrrolizidine alkaloids (PAs) are a widespread group of secondary metabolites in plants. PAs are notorious for their acute hepatotoxicity, genotoxicity and neurological damage to humans and animals. In recent decades, the application of PAs for beneficial biological activities to cure disease has drawn greater attention. Here, we review the current knowledge regarding the pharmacological properties of PAs and discuss PAs as promising prototypes for the development of new drugs.
吡咯里西啶生物碱（PAs）是植物中广泛存在的一类次生代谢物。PAs 以其对人类和动物的急性肝毒性、遗传毒性和神经毒性而臭名昭著。近几十年来，人们越来越关注将 PAs 应用于有益的生物活性以治疗疾病。在这里，我们综述了 PAs 的药理学特性的现有知识，并讨论了 PAs 作为开发新药的有前途的原型。
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