Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Department of Microbiology & Immunology, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Molecules. 2019 Apr 19;24(8):1552. doi: 10.3390/molecules24081552.
Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-inflammatory, and hepatoprotective functions. Recent studies have also documented the antiviral activities of silymarin and its derivatives against several viruses, including the flaviviruses (hepatitis C virus and dengue virus), togaviruses (Chikungunya virus and Mayaro virus), influenza virus, human immunodeficiency virus, and hepatitis B virus. This review will describe some of the latest preclinical and clinical studies detailing the antiviral profiles of silymarin and its derivatives, and discuss their relevance for antiviral drug development.
水飞蓟素类黄酮木脂素是众所周知的具有抗氧化、抗炎和保肝作用的药物。最近的研究还记录了水飞蓟素及其衍生物对几种病毒（包括黄病毒（丙型肝炎病毒和登革热病毒）、披膜病毒（基孔肯雅病毒和马亚罗病毒）、流感病毒、人类免疫缺陷病毒和乙型肝炎病毒）的抗病毒活性。这篇综述将描述一些最新的临床前和临床研究，详细介绍水飞蓟素及其衍生物的抗病毒谱，并讨论它们在抗病毒药物开发方面的相关性。
