Kohnert Eva, Kreutz Clemens, Binder Nadine, Hannibal Luciana, Gorkiewicz Gregor, Müller Alexander, Storz Maximilian Andreas, Huber Roman, Lederer Ann-Kathrin
Institute of Medical Biometry and Statistics, Medical Center, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
Institute of Digitalization in Medicine, Medical Center, Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany.
Microorganisms. 2021 Mar 31;9(4):727. doi: 10.3390/microorganisms9040727.
An essential role of the gut microbiota in health and disease is strongly suggested by recent research. The composition of the gut microbiota is modified by multiple internal and external factors, such as diet. A vegan diet is known to show beneficial health effects, yet the role of the gut microbiota is unclear. Within a 4-week, monocentric, randomized, controlled trial with a parallel group design (vegan (VD) vs. meat-rich (MD)) with 53 healthy, omnivore, normal-weight participants (62% female, mean 31 years of age), fecal samples were collected at the beginning and at the end of the trial and were analyzed using 16S rRNA gene amplicon sequencing (Clinical Trial register: DRKS00011963). Alpha diversity as well as beta diversity did not differ significantly between MD and VD. Plotting of baseline and end samples emphasized a highly intra-individual microbial composition. Overall, the gut microbiota was not remarkably altered between VD and MD after the trial. was found to be increased in VD while being decreased in MD. and were increased in MD while being decreased in VD. Importantly, changes in genera and should be subjected to intense investigation as markers for physical and mental health.
近期研究强烈表明肠道微生物群在健康和疾病中起着至关重要的作用。肠道微生物群的组成会受到多种内部和外部因素的影响，比如饮食。众所周知，纯素饮食对健康有益，但肠道微生物群在其中所起的作用尚不清楚。在一项为期4周的单中心、随机、平行组对照试验（纯素饮食组（VD）与富含肉类饮食组（MD））中，招募了53名健康的、杂食的、体重正常的参与者（62%为女性，平均年龄31岁），在试验开始和结束时采集粪便样本，并使用16S rRNA基因扩增子测序进行分析（临床试验注册号：DRKS00011963）。MD组和VD组之间的α多样性以及β多样性没有显著差异。对基线样本和结束样本的绘图强调了个体内部高度的微生物组成。总体而言，试验后VD组和MD组之间的肠道微生物群没有明显变化。发现[此处原文缺失具体指标]在VD组中增加而在MD组中减少。[此处原文缺失具体指标]和[此处原文缺失具体指标]在MD组中增加而在VD组中减少。重要的是，[此处原文缺失具体属名]属和[此处原文缺失具体属名]属的变化作为身心健康的标志物应受到深入研究。
