Camba-Gómez Miguel, Gualillo Oreste, Conde-Aranda Javier
Molecular and Cellular Gastroenterology, Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.
SERGAS (Servizo Galego de Saúde) and IDIS (Instituto de Investigación Sanitaria de Santiago), The NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Research Laboratory 9, Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain.
Int J Mol Sci. 2021 Mar 5;22(5):2605. doi: 10.3390/ijms22052605.
Inflammation is an essential physiological process that is directed to the protection of the organism against invading pathogens or tissue trauma. Most of the existing knowledge related to inflammation is focused on the factors and mechanisms that drive the induction phase of this process. However, since the recognition that the resolution of the inflammation is an active and tightly regulated process, increasing evidence has shown the relevance of this process for the development of chronic inflammatory diseases, such as inflammatory bowel disease. For that reason, with this review, we aimed to summarize the most recent and interesting information related to the resolution process in the context of intestinal inflammation. We discussed the advances in the understanding of the pro-resolution at intestine level, as well as the new mediators with pro-resolutive actions that could be interesting from a therapeutic point of view.
炎症是一种重要的生理过程，旨在保护机体抵御入侵病原体或组织损伤。目前关于炎症的大多数现有知识都集中在驱动该过程诱导阶段的因素和机制上。然而，自从认识到炎症的消退是一个活跃且受到严格调控的过程以来，越来越多的证据表明该过程与慢性炎症性疾病（如炎症性肠病）的发展相关。因此，通过本综述，我们旨在总结在肠道炎症背景下与消退过程相关的最新且有趣的信息。我们讨论了在肠道水平上对促消退的理解进展，以及从治疗角度来看可能具有意义的具有促消退作用的新介质。
