苄氧基烷醇类对松材线虫的杀线虫活性。

Nematicidal Activity of Benzyloxyalkanols against Pine Wood Nematode.

机构信息

Forest Insect Pests and Disease Division, National Institute of Forest Science, Seoul 02455, Korea.

Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.

出版信息

Biomolecules. 2021 Mar 5;11(3):384. doi: 10.3390/biom11030384.

DOI:10.3390/biom11030384

PMID:33807784

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7999353/

Abstract

Pine wilt disease (PWD) is caused by the pine wood nematode (PWN; ) and causes severe environmental damage to global pine forest ecosystems. The current strategies used to control PWN are mainly chemical treatments. However, the continuous use of these reagents could result in the development of pesticide-resistant nematodes. Therefore, the present study was undertaken to find potential alternatives to the currently used PWN control agents abamectin and emamectin. Benzyloxyalkanols (BzOROH; R = C-C) were synthesized and the nematicidal activity of the synthetic compounds was investigated. Enzymatic inhibitory assays (acetylcholinesterase (AChE) and glutathione -transferase (GST)) were performed with BzOC8OH and BzOC9OH to understand their mode of action. The benzyloxyalkanols showed higher nematicidal activity than did benzyl alcohol. Among the tested BzOROHs, BzC8OH and BzC9OH showed the strongest nematicidal activity. The LD values of BzC8OH and BzC9OH were 246.1 and 158.0 ppm, respectively. No enzyme inhibitory activity was observed for BzC8OH and BzC9OH. The results suggested that benzyloxyalcohols could be an alternative nematicidal agent.

摘要

松材线虫病（PWD）是由松材线虫（PWN；）引起的，对全球松林生态系统造成严重的环境破坏。目前用于控制 PWN 的策略主要是化学处理。然而，这些试剂的持续使用可能导致抗药性线虫的产生。因此，本研究旨在寻找替代目前使用的 PWN 控制剂阿维菌素和甲氨基阿维菌素苯甲酸盐的潜在替代品。合成了苯氧烷醇（BzOROH；R = C-C），并研究了合成化合物的杀线虫活性。用 BzOC8OH 和 BzOC9OH 进行了酶抑制测定（乙酰胆碱酯酶（AChE）和谷胱甘肽 -S-转移酶（GST）），以了解它们的作用方式。苯氧烷醇的杀线虫活性高于苯甲醇。在所测试的 BzOROH 中，BzC8OH 和 BzC9OH 表现出最强的杀线虫活性。BzC8OH 和 BzC9OH 的 LD 值分别为 246.1 和 158.0 ppm。BzC8OH 和 BzC9OH 没有表现出酶抑制活性。结果表明，苯氧烷醇类化合物可能是一种替代杀线虫剂。