Ayaz Muhammad, Sadiq Abdul, Junaid Muhammad, Ullah Farhat, Subhan Fazal, Ahmed Jawad
Department of Pharmacy, University of MalakandChakdara, Pakistan.
Department of Pharmacy, University of PeshawarPeshawar, Pakistan.
Front Aging Neurosci. 2017 May 30;9:168. doi: 10.3389/fnagi.2017.00168. eCollection 2017.
The use of essential oils (EOs) and their components is known since long in traditional medicine and aromatherapy for the management of various diseases, and is further increased in the recent times. The neuroprotective and anti-aging potentials of EOs and their possible mechanism of actions were evaluated by numerous researchers around the globe. Several clinically important EOs and their components from , and so many other plants are reported for neuroprotective effects. This review article was aimed to summarize the current finding on EOs tested against neurodegenerative disorders like Alzheimer disease (AD) and dementia. The effects of EOs on pathological targets of AD and dementia including amyloid deposition (Aβ), neurofibrillary tangles (NFTs), cholinergic hypofunction, oxidative stress and glutamatergic abnormalities were focused. Furthermore, effects of EOs on other neurological disorders including anxiety, depression, cognitive hypofunction epilepsy and convulsions were also evaluated in detail. In conclusion, EOs were effective on several pathological targets and have improved cognitive performance in animal models and human subjects. Thus, EOs can be developed as multi-potent agents against neurological disorders with better efficacy, safety and cost effectiveness.
在传统医学和芳香疗法中，使用精油（EOs）及其成分来治疗各种疾病由来已久，且近年来其应用进一步增加。全球众多研究人员对精油及其成分的神经保护和抗衰老潜力及其可能的作用机制进行了评估。据报道，来自多种植物的几种具有临床重要性的精油及其成分具有神经保护作用。这篇综述文章旨在总结目前针对阿尔茨海默病（AD）和痴呆等神经退行性疾病测试精油的研究结果。重点关注了精油对AD和痴呆病理靶点的影响，包括淀粉样蛋白沉积（Aβ）、神经原纤维缠结（NFTs）、胆碱能功能减退、氧化应激和谷氨酸能异常。此外，还详细评估了精油对其他神经系统疾病的影响，包括焦虑、抑郁、认知功能减退、癫痫和惊厥。总之，精油对多个病理靶点有效，并在动物模型和人类受试者中改善了认知表现。因此，精油可以开发成为针对神经系统疾病的多效性药物，具有更好的疗效、安全性和成本效益。
