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口服非甾体抗炎药——一般特性及在颞下颌关节骨关节炎治疗中的应用——一篇叙述性综述

Orally Administered NSAIDs-General Characteristics and Usage in the Treatment of Temporomandibular Joint Osteoarthritis-A Narrative Review.

作者信息

Derwich Marcin, Mitus-Kenig Maria, Pawlowska Elzbieta

机构信息

ORTODENT, Specialist Orthodontic Private Practice in Grudziadz, 86-300 Grudziadz, Poland.

Department of Experimental Dentistry and Prophylaxis, Medical College, Jagiellonian University in Krakow, 31-008 Krakow, Poland.

出版信息

Pharmaceuticals (Basel). 2021 Mar 5;14(3):219. doi: 10.3390/ph14030219.

DOI:10.3390/ph14030219
PMID:33807930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7998670/
Abstract

: Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative joint disease. The aim of this review was to present the general characteristics of orally administered nonsteroidal anti-inflammatory drugs (NSAIDs) and to present the efficacy of NSAIDs in the treatment of TMJ OA. : PubMed database was analyzed with the keywords: "(temporomandibular joint) AND ((disorders) OR (osteoarthritis) AND (treatment)) AND (nonsteroidal anti-inflammatory drug)". After screening of 180 results, 6 studies have been included in this narrative review. : Nonsteroidal anti-inflammatory drugs are one of the most commonly used drugs for alleviation of pain localized in the orofacial area. The majority of articles predominantly examined and described diclofenac sodium in the treatment of pain in the course of TMJ OA. Because of the limited number of randomized studies evaluating the efficacy of NSAIDs in the treatment of TMJ OA, as well as high heterogeneity of published researches, it seems impossible to draw up unequivocal recommendations for the usage of NSAIDs in the treatment of TMJ OA. However, it is highly recommended to use the lowest effective dose of NSAIDs for the shortest possible time. Moreover, in patients with increased risk of gastrointestinal complications, supplementary gastroprotective agents should be prescribed.

摘要

颞下颌关节骨关节炎（TMJ OA）是一种退行性关节疾病。本综述的目的是介绍口服非甾体抗炎药（NSAIDs）的一般特性，并阐述NSAIDs在治疗TMJ OA中的疗效。通过在PubMed数据库中使用关键词“（颞下颌关节）AND（（疾病）OR（骨关节炎）AND（治疗））AND（非甾体抗炎药）”进行分析。在筛选出的180项结果中，本叙述性综述纳入了6项研究。非甾体抗炎药是缓解口面部局部疼痛最常用的药物之一。大多数文章主要研究和描述了双氯芬酸钠在治疗TMJ OA过程中的疼痛情况。由于评估NSAIDs治疗TMJ OA疗效的随机研究数量有限，以及已发表研究的高度异质性，似乎无法就NSAIDs在治疗TMJ OA中的使用制定明确的建议。然而，强烈建议在尽可能短的时间内使用最低有效剂量的NSAIDs。此外，对于胃肠道并发症风险增加的患者，应开具补充性胃保护剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/7998670/6fb295501633/pharmaceuticals-14-00219-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/7998670/729e8cc48cdc/pharmaceuticals-14-00219-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/7998670/586ff0d4732c/pharmaceuticals-14-00219-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/7998670/c97a7a59150b/pharmaceuticals-14-00219-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/7998670/6fb295501633/pharmaceuticals-14-00219-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/7998670/729e8cc48cdc/pharmaceuticals-14-00219-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/7998670/586ff0d4732c/pharmaceuticals-14-00219-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/7998670/c97a7a59150b/pharmaceuticals-14-00219-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/7998670/6fb295501633/pharmaceuticals-14-00219-g004.jpg

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