Taniguchi Mariko, Ueda Yutaka, Yagi Asami, Miyoshi Ai, Tanaka Yusuke, Minekawa Ryoko, Endo Masayuki, Tomimatsu Takuji, Hirai Kei, Nakayama Tomio, Kimura Tadashi
Department of Obstetrics and Gynecology, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita 565-0871, Osaka, Japan.
Department of Obstetrics and Gynecology, Osaka Rosai Hospital, 1179-3 Nagasone-cho, Sakai 591-8025, Osaka, Japan.
Vaccines (Basel). 2021 Mar 19;9(3):280. doi: 10.3390/vaccines9030280.
Women born between 1994 and 1999 achieved high vaccination rates for human papillomavirus (HPV); they are now reaching the age of cervical cancer screening programs in Japan. In this study, we aimed to investigate the health awareness of HPV-vaccinated and unvaccinated women and to create tailored leaflets recommending cervical cancer screening for each. Surveys on the cancer screening rates for HPV-vaccinated and unvaccinated women aged 20 and 21 have demonstrated that the rate was significantly higher ( < 0.01) in vaccinated (6.2%) than in unvaccinated women (3.1%). Next, interviews and Internet questionnaires clarified that there was a trend that vaccinated women have a better health consciousness than the unvaccinated ones, and that in unvaccinated women, their willingness to receive cervical cancer screening was significantly enhanced by the fear of developing cancer. Finally, in a prospective study, the increase in the screening rate for both vaccinated and unvaccinated groups after they read tailored leaflets, from 6.4% to 7.4% and from 3.9% to 5.1%, respectively, was not statistically significant compared to the groups provided with a standard reminder letter. Cervical cancer control measures might be enhanced by recommending cervical cancer screening in ways better tailored to HPV vaccination status.
1994年至1999年出生的女性实现了较高的人乳头瘤病毒（HPV）疫苗接种率；她们现在正步入日本宫颈癌筛查项目的年龄阶段。在本研究中，我们旨在调查接种HPV疫苗和未接种HPV疫苗的女性的健康意识，并为她们分别制作针对性的宫颈癌筛查推荐传单。对20岁和21岁接种HPV疫苗和未接种HPV疫苗的女性的癌症筛查率调查表明，接种疫苗者（6.2%）的筛查率显著高于未接种疫苗者（3.1%）（<0.01）。接下来，通过访谈和网络问卷明确，接种疫苗的女性比未接种疫苗的女性有更好的健康意识这一趋势，并且在未接种疫苗的女性中，她们对患癌的恐惧显著增强了接受宫颈癌筛查的意愿。最后，在一项前瞻性研究中，接种疫苗组和未接种疫苗组在阅读针对性传单后的筛查率分别从6.4%提高到7.4%和从3.9%提高到5.1%，与收到标准提醒信的组相比，差异无统计学意义。通过以更适合HPV疫苗接种状况的方式推荐宫颈癌筛查，可能会加强宫颈癌控制措施。
