LaPenna Kyle B, Polhemus David J, Doiron Jake E, Hidalgo Hunter A, Li Zhen, Lefer David J
Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Antioxidants (Basel). 2021 Mar 19;10(3):485. doi: 10.3390/antiox10030485.
Hydrogen sulfide (HS) is an endogenous, gaseous signaling molecule that plays a critical role in cardiac and vascular biology. HS regulates vascular tone and oxidant defenses and exerts cytoprotective effects in the heart and circulation. Recent studies indicate that HS modulates various components of metabolic syndrome, including obesity and glucose metabolism. This review will discuss studies exhibiting HS -derived cardioprotective signaling in heart failure with reduced ejection fraction (HFrEF). We will also discuss the role of HS in metabolic syndrome and heart failure with preserved ejection fraction (HFpEF).
硫化氢（HS）是一种内源性气态信号分子，在心脏和血管生物学中起着关键作用。HS调节血管张力和氧化防御，并在心脏和循环系统中发挥细胞保护作用。最近的研究表明，HS可调节代谢综合征的各种成分，包括肥胖和葡萄糖代谢。本综述将讨论在射血分数降低的心力衰竭（HFrEF）中显示HS衍生的心脏保护信号的研究。我们还将讨论HS在代谢综合征和射血分数保留的心力衰竭（HFpEF）中的作用。
