Institute of Molecular Biology and Pathology, Italian National Research Council (CNR-IBPM), 00185 Rome, Italy.
Department of Anatomical, Histological, Forensic and Orthopedic Sciences, "Sapienza" University of Rome, Viale Regina Elena 336, 00161 Rome, Italy.
Int J Mol Sci. 2021 Mar 19;22(6):3151. doi: 10.3390/ijms22063151.
Endometrial cancer (EC) has been classified over the years, for prognostic and therapeutic purposes. In recent years, classification systems have been emerging not only based on EC clinical and pathological characteristics but also on its genetic and epigenetic features. Noncoding RNAs (ncRNAs) are emerging as promising markers in several cancer types, including EC, for which their prognostic value is currently under investigation and will likely integrate the present prognostic tools based on protein coding genes. This review aims to underline the importance of the genetic and epigenetic events in the EC tumorigenesis, by expounding upon the prognostic role of ncRNAs.
子宫内膜癌（EC）多年来一直为了预测和治疗目的进行分类。近年来，分类系统不仅基于 EC 的临床和病理特征，还基于其遗传和表观遗传特征而出现。非编码 RNA（ncRNA）在包括 EC 在内的几种癌症类型中作为有前途的标志物而出现，目前正在研究其预后价值，并可能整合基于蛋白编码基因的现有预后工具。本文通过阐述 ncRNA 的预后作用，强调了 EC 肿瘤发生中遗传和表观遗传事件的重要性。
