Donegani Maria Isabella, Miceli Alberto, Pardini Matteo, Bauckneht Matteo, Chiola Silvia, Pennone Michele, Marini Cecilia, Massa Federico, Raffa Stefano, Ferrarazzo Giulia, Arnaldi Dario, Sambuceti Gianmario, Nobili Flavio, Morbelli Silvia
IRCCS Ospedale Policlinico San Martino, 16131 Genova, Italy.
Nuclear Medicine Unit, Department of Health Sciences, University of Genoa, 516126 Genoa, Italy.
Biomedicines. 2021 Mar 12;9(3):287. doi: 10.3390/biomedicines9030287.
We aimed to evaluate the brain hypometabolic signature of persistent isolated olfactory dysfunction after SARS-CoV-2 infection. Twenty-two patients underwent whole-body [F]-FDG PET, including a dedicated brain acquisition at our institution between May and December 2020 following their recovery after SARS-Cov2 infection. Fourteen of these patients presented isolated persistent hyposmia (smell diskettes olfaction test was used). A voxel-wise analysis (using Statistical Parametric Mapping software version 8 (SPM8)) was performed to identify brain regions of relative hypometabolism in patients with hyposmia with respect to controls. Structural connectivity of these regions was assessed (BCB toolkit). Relative hypometabolism was demonstrated in bilateral parahippocampal and fusiform gyri and in left insula in patients with respect to controls. Structural connectivity maps highlighted the involvement of bilateral longitudinal fasciculi. This study provides evidence of cortical hypometabolism in patients with isolated persistent hyposmia after SARS-Cov2 infection. [F]-FDG PET may play a role in the identification of long-term brain functional sequelae of COVID-19.
我们旨在评估新型冠状病毒2（SARS-CoV-2）感染后持续性孤立嗅觉功能障碍的脑代谢减退特征。2020年5月至12月期间，22名患者在我院接受了全身[F] -氟代脱氧葡萄糖（FDG）正电子发射断层显像（PET）检查，这些患者在感染SARS-CoV-2康复后进行了专门的脑部显像。其中14名患者表现为孤立性持续性嗅觉减退（采用嗅觉盘嗅觉测试）。采用体素分析（使用统计参数映射软件版本8（SPM8））来确定嗅觉减退患者相对于对照组脑代谢相对减退的区域。评估了这些区域的结构连接性（BCB工具包）。与对照组相比，患者双侧海马旁回和梭状回以及左侧岛叶出现相对代谢减退。结构连接图谱突出显示双侧纵向束的受累情况。本研究为SARS-CoV-2感染后孤立性持续性嗅觉减退患者的皮质代谢减退提供了证据。[F] -FDG PET可能在识别新型冠状病毒肺炎（COVID-19）的长期脑功能后遗症方面发挥作用。
