Melamed Eyal, Kiambi Patrick, Okoth Dancan, Honigber Irena, Tamir Eran, Borkow Gadi
Department of Orthopedics, Rambam Medical Center, Haifa 31096, Israel.
Dermatology Unit, Kenyatta National Hospital, Nairobi 00202, Kenya.
Medicina (Kaunas). 2021 Mar 22;57(3):296. doi: 10.3390/medicina57030296.
Novel antimicrobial wound dressings impregnated with copper oxide micro-particles have been cleared for treatment of acute and chronic wounds. Our objective is to provide preliminary data regarding the potential benefit of using these novel wound dressings including in non-infected wounds. Methods involved the treatment of wounds that responded partially or poorly to conventional wound healing treatments with copper oxide impregnated wound dressings in patients with a range of etiologies. Ten cases of patients with etiologies such as diabetes mellitus, sickle cell disease, renal failure, and necrotizing fasciitis, in which the application of copper oxide impregnated wound dressings in infected and non-infected wounds, which resulted in significant enhanced wound healing, are presented. This was exemplified by clearing of the wound infections, reduction of the fibrous and/or necrotic tissue and by intense granulation, epithelialization, and wound closure. The described 10 case reports support our hypothesis that the copper oxide-containing wound dressing not only confers protection to the wound and the dressing from microbial contamination, and in some cases may help clear the wound infections, but in addition and more importantly, stimulate skin regeneration and wound healing. Our findings are in line with previous animal and in vitro studies showing that copper plays a key role in angiogenesis and skin regeneration. These case reports support the notion that the use of copper oxide impregnated wound dressings may be an important intervention in the arsenal of wound treatment modalities, especially in hard to heal wounds.
含有氧化铜微粒的新型抗菌伤口敷料已获批用于治疗急慢性伤口。我们的目标是提供关于使用这些新型伤口敷料潜在益处的初步数据，包括在未感染伤口中的应用。方法包括用氧化铜浸渍伤口敷料治疗一系列病因患者中对传统伤口愈合治疗反应部分不佳或欠佳的伤口。本文介绍了10例病因如糖尿病、镰状细胞病、肾衰竭和坏死性筋膜炎的患者，在其感染和未感染伤口中应用氧化铜浸渍伤口敷料后，伤口愈合显著加快。这表现为伤口感染清除、纤维性和/或坏死组织减少以及强烈的肉芽形成、上皮化和伤口闭合。所描述的10例病例报告支持了我们的假设，即含氧化铜的伤口敷料不仅能保护伤口和敷料免受微生物污染，在某些情况下还可能有助于清除伤口感染，而且更重要的是，能刺激皮肤再生和伤口愈合。我们的研究结果与先前的动物和体外研究一致，表明铜在血管生成和皮肤再生中起关键作用。这些病例报告支持了这样一种观点，即使用氧化铜浸渍伤口敷料可能是伤口治疗方式中的一项重要干预措施，尤其是在难愈合伤口的治疗中。
