Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE) e Instituto de Biología Molecular y Celular (IBMC), Miguel Hernández University (UMH), Elche, 03202, Alicante, Spain.
Institute of Bioengineering and Department of Applied Biology-Nutrition, University Miguel Hernandez, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante, Spain.
Sci Rep. 2019 Feb 28;9(1):2999. doi: 10.1038/s41598-019-39159-5.
Plant-polyphenols have shown the capacity to ameliorate obesity-induced metabolic disturbances, both in cell and animal models, where most therapeutic approaches have failed. On the basis of previous research, a dietary supplement containing 500 mg of a combination of polyphenolic extracts from Lippia citriodora L. and Hibiscus sabdariffa L. (LC-HS), in the context of an equilibrated isocaloric diet, was evaluated in a double blind, placebo-controlled and randomized trial in 56 obese/overweight subjects for two months. Compared to controls, the consumption of the LC-HS polyphenols showed significant improvements in body weight, abdominal circumference of overweight subjects (-6.79 ± 0.80 cm in overweight LC-HS group vs -1.85 ± 0.83 cm in controls, p < 0.001) and body fat % (-1.33 ± 0.15% in overweight LC-HS group vs -0.66 ± 0.17% in controls, p < 0.05). Heart rate and systolic blood pressure also presented significant improvements in overweight LC-HS participants. However, changes were more modest in obese subjects. Further, LC-HS extract significantly reduced lipid content and increased AMPK activity in a hypertrophied adipocyte cell model. Therefore, consumption of 500 mg/day of LC-HS extracts enriched in polyphenols for two months in the context of an isocaloric diet by overweight subjects decreased symptoms associated to obesity-related diseases. Modulation of fat metabolism in adipose tissue, probably mediated by AMPK activation, is proposed as a molecular target to be explored in future research.
植物多酚已被证明具有改善肥胖引起的代谢紊乱的能力，无论是在细胞还是动物模型中，大多数治疗方法都失败了。基于先前的研究，在均衡等热量饮食的背景下，一种含有 500 毫克 Lippia citriodora L. 和 Hibiscus sabdariffa L. 的多酚提取物组合的膳食补充剂（LC-HS），在 56 名肥胖/超重受试者中进行了为期两个月的双盲、安慰剂对照和随机试验。与对照组相比，LC-HS 多酚的消耗在超重受试者的体重（超重 LC-HS 组为-6.79 ± 0.80cm，对照组为-1.85 ± 0.83cm，p < 0.001）和体脂肪百分比（超重 LC-HS 组为-1.33 ± 0.15%，对照组为-0.66 ± 0.17%，p < 0.05）方面显示出显著改善。超重 LC-HS 参与者的心率和收缩压也有显著改善。然而，在肥胖受试者中变化更为温和。此外，LC-HS 提取物在肥大脂肪细胞模型中显著降低了脂质含量并增加了 AMPK 活性。因此，超重受试者在均衡等热量饮食的背景下，每天消耗 500 毫克富含多酚的 LC-HS 提取物两个月，可减轻与肥胖相关疾病相关的症状。脂肪代谢在脂肪组织中的调节，可能通过 AMPK 激活介导，被提议作为未来研究中探索的分子靶点。
