Department of Physical Medicine and Rehabilitation, University of Miami Miller School of Medicine, Miami, Florida.
The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida.
Top Spinal Cord Inj Rehabil. 2021;27(1):1-10. doi: 10.46292/sci20-00067.
Individuals with a spinal cord injury (SCI) have a unique physiology characterized by sarcopenia, neurogenic osteoporosis, neurogenic anabolic deficiency, sympathetic dysfunction, and blunted satiety associated with their SCI, all of which alter energy balance and subsequently body composition. The distinct properties of "neurogenic obesity" place this population at great risk for metabolic dysfunction, including systemic inflammation, hyperglycemia, dyslipidemia, and hypertension. The purpose of this article is to demonstrate the relationship between neurogenic obesity and the metabolic syndrome after SCI, highlighting the mechanisms associated with adipose tissue pathology and those respective comorbidities. Additionally, representative studies of persons with SCI will be provided to elucidate the severity of the problem and to prompt greater vigilance among SCI specialists as well as primary care providers in order to better manage the epidemic from a public health perspective.
脊髓损伤（SCI）患者的生理学特点独特，表现为肌肉减少症、神经性骨质疏松症、神经性合成代谢不足、交感神经功能障碍和与 SCI 相关的饱腹感迟钝，所有这些都会改变能量平衡，进而影响身体成分。“神经性肥胖”的特殊性质使该人群面临代谢功能障碍的巨大风险，包括全身炎症、高血糖、血脂异常和高血压。本文的目的是展示 SCI 后神经性肥胖与代谢综合征之间的关系，重点介绍与脂肪组织病理学相关的机制以及各自的合并症。此外，还将提供 SCI 患者的代表性研究，以阐明问题的严重程度，并促使 SCI 专家以及初级保健提供者提高警惕，从公共卫生角度更好地管理这一流行疾病。
