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长期暴露于环境空气污染与心肌梗死：一项系统评价和荟萃分析。

Long-Term Exposure to Ambient Air Pollution and Myocardial Infarction: A Systematic Review and Meta-Analysis.

作者信息

Zou Li, Zong Qiao, Fu Wenning, Zhang Zeyu, Xu Hongbin, Yan Shijiao, Mao Jin, Zhang Yan, Cao Shiyi, Lv Chuanzhu

机构信息

Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.

Department of Neurology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.

出版信息

Front Med (Lausanne). 2021 Mar 17;8:616355. doi: 10.3389/fmed.2021.616355. eCollection 2021.

DOI:10.3389/fmed.2021.616355
PMID:33816520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8010182/
Abstract

An increasing number of epidemiological original studies suggested that long-term exposure to particulate matter (PM5 and PM) could be associated with the risk of myocardial infarction (MI), but the results were inconsistent. We aimed to synthesized available cohort studies to identify the association between ambient air pollution (PM and PM) and MI risk by a meta-analysis. PubMed and Embase were searched through September 2019 to identify studies that met predetermined inclusion criteria. Reference lists from retrieved articles were also reviewed. A random-effects model was used to calculate the pooled relative risk (RR) and 95% confidence intervals (CI). Twenty-seven cohort studies involving 6,764,987 participants and 94,540 patients with MI were included in this systematic review. The pooled results showed that higher levels of ambient air pollution (PM and PM) exposure were significantly associated with the risk of MI. The pooled relative risk (RR) for each 10-μg/m increment in PM and PM were 1.18 (95% CI: 1.11-1.26), and 1.03 (95% CI: 1.00-1.05), respectively. Exclusion of any single study did not materially alter the combined risk estimate. Integrated evidence from cohort studies supports the hypothesis that long-term exposure to PM and PM is a risk factor for MI.

摘要

越来越多的流行病学原始研究表明，长期暴露于颗粒物（PM5和PM）可能与心肌梗死（MI）风险相关，但结果并不一致。我们旨在综合现有队列研究，通过荟萃分析确定环境空气污染（PM和PM）与MI风险之间的关联。检索了截至2019年9月的PubMed和Embase，以识别符合预定纳入标准的研究。还对检索文章的参考文献列表进行了审查。采用随机效应模型计算合并相对风险（RR）和95%置信区间（CI）。本系统评价纳入了27项队列研究，涉及6764987名参与者和94540例MI患者。汇总结果显示，更高水平的环境空气污染（PM和PM）暴露与MI风险显著相关。PM和PM每增加10μg/m，合并相对风险（RR）分别为1.18（95%CI：1.11-1.26）和1.03（95%CI：1.00-1.05）。排除任何一项研究都不会实质性改变合并风险估计。队列研究的综合证据支持以下假设：长期暴露于PM和PM是MI的一个风险因素。

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