口服伤寒疫苗Ty21a的对照现场试验。
A controlled field trial of liver oral typhoid vaccine Ty21a.
作者信息
Wahdan M H, Serie C, Germanier R, Lackany A, Cerisier Y, Guerin N, Sallam S, Geoffroy P, el Tantawi A S, Guesry P
出版信息
Bull World Health Organ. 1980;58(3):469-74.
A controlled field trial of a live oral typhoid vaccine was carried out in Alexandria, Egypt, in 1978-79. A total of 32 388 children were included in the study. They were divided in two comparable groups, one given 3 doses of the vaccine and the other 3 doses of the placebo. Each active dose contained 1 x 10(9)-8 x 10(9) live Ty21a bacteria. From March 1978 to March 1979, the population studied was followed up and suspected typhoid cases were investigated bacteriologically and serologically. The effectiveness of the vaccine was assessed by analysis of the incidence of typhoid fever in the two groups. The results of the follow-up indicate that, in the dosage schedule used, the Ty21a mutant strain, found previously to be stable and safe, is protective against typhoid fever for at least one year.
1978 - 1979年在埃及亚历山大进行了一项口服伤寒活疫苗的对照现场试验。共有32388名儿童参与了该研究。他们被分成两个可比组，一组接种3剂疫苗，另一组接种3剂安慰剂。每剂活性疫苗含有1×10⁹ - 8×10⁹ 活的Ty21a细菌。从1978年3月到1979年3月，对研究人群进行了随访，并对疑似伤寒病例进行了细菌学和血清学调查。通过分析两组伤寒热的发病率来评估疫苗的有效性。随访结果表明，在所使用的剂量方案中，先前发现稳定且安全的Ty21a突变株对伤寒热具有至少一年的保护作用。
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