Favier R J, Koubi H E
Laboratoire de Physiologie, UA 621 and 181 Centre National de la Recherche Scientifique, Lyon, France.
Am J Physiol. 1988 Jun;254(6 Pt 2):R877-84. doi: 10.1152/ajpregu.1988.254.6.R877.
The effect of repetitive alternance of 3 days fasting and 3 days refeeding on morphological and biochemical ability to perform exercise was investigated in adult male rats. At the end of 10 wk of chronic intermittent fasting, the rats had consumed 20% less food but were able to maintain their initial body weight. Intermittent fasted rats (IF) had significantly lower carcass fat but had maintained the percent contribution of proteins to total carcass weight. The relative mass of liver, heart, kidney, and muscles was not affected by such dietary manipulation. Both glycolytic and oxidative enzyme capacities were reduced in IF rat muscles. In response to exercise (2 h of swimming), control rats displayed hypoglycemia, whereas IF rats were able to maintain plasma glucose level in spite of a reduced energy supply from liver (low glycogen stores) and adipose tissue (low plasma free fatty acid levels). This had been obtained by accumulating glycogen and triglycerides in muscles and by deriving energy for muscular contraction from the in situ breakdown of these energetic substrates. In addition, although IF rats displayed a markedly reduced liver protein content, the liver exercise-induced protein breakdown was abolished in these animals.
在成年雄性大鼠中研究了3天禁食和3天再喂养的重复交替对运动形态学和生化能力的影响。在10周慢性间歇性禁食结束时，大鼠的食物摄入量减少了20%，但能够维持其初始体重。间歇性禁食大鼠（IF）的体脂明显较低，但蛋白质占总体重的百分比保持不变。肝脏、心脏、肾脏和肌肉的相对质量不受这种饮食操作的影响。IF大鼠肌肉中的糖酵解和氧化酶能力均降低。在运动（游泳2小时）时，对照大鼠出现低血糖，而IF大鼠尽管肝脏（糖原储备低）和脂肪组织（血浆游离脂肪酸水平低）的能量供应减少，但仍能维持血浆葡萄糖水平。这是通过在肌肉中积累糖原和甘油三酯以及从这些能量底物的原位分解中获取肌肉收缩能量来实现的。此外，尽管IF大鼠的肝脏蛋白质含量明显降低，但这些动物肝脏运动诱导的蛋白质分解被消除。
