Sakamoto K, Grunewald K K
J Nutr. 1987 Feb;117(2):390-5. doi: 10.1093/jn/117.2.390.
An 8-wk trial was conducted to compare the effects of exercise and intermittent fasting, either singly or combined, on growth responses of rats. Four-week-old male Wistar rats, 85-110 g each, were assigned to one of four groups (n = 9): control, exercise on a motor-driven treadmill, fasting every other day (EOD) and fasting EOD and exercise combined. At the end of the trial, the exercised rats had consumed 7% less feed, had gained 7% less weight and had 36% less carcass fat than the control rats. Fasting on alternate days markedly reduced the growth rate of the young rats. Fasted-EOD rats weighed less than half as much as the control rats, had 64% less carcass fat and 51% less lean mass and had smaller livers, kidneys, hearts, tibias and tibialis anterior muscles. The addition of exercise to the fasting EOD regimen improved the growth of the animals. When the fasted-EOD rats were also exercised, they gained 29% more weight, consumed 11% more feed and had carcasses that contained 29% more lean mass and 18% less fat than the fasted-EOD rats. The data suggest that exercise may be beneficial where feed restriction is episodic, allowing some capacity for catch-up growth.
进行了一项为期8周的试验，以比较运动和间歇性禁食单独或联合使用对大鼠生长反应的影响。将4周龄、体重85 - 110克的雄性Wistar大鼠分为四组（每组n = 9）：对照组、在电动跑步机上运动组、隔日禁食组以及隔日禁食并运动联合组。试验结束时，与对照组大鼠相比，运动组大鼠的饲料摄入量减少了7%，体重增加减少了7%，胴体脂肪减少了36%。隔日禁食显著降低了幼鼠的生长速度。隔日禁食的大鼠体重不到对照组大鼠的一半，胴体脂肪减少了64%，瘦肉量减少了51%，肝脏、肾脏、心脏、胫骨和胫骨前肌也较小。在隔日禁食方案中加入运动改善了动物的生长情况。当隔日禁食的大鼠也进行运动时，与隔日禁食大鼠相比，它们的体重增加了29%，饲料摄入量增加了11%，胴体中的瘦肉量增加了29%，脂肪减少了18%。数据表明，在饲料限制是间歇性的情况下，运动可能有益，可使动物具备一定的追赶生长能力。
