Hodge Jacob G, Zamierowski David S, Robinson Jennifer L, Mellott Adam J
Bioengineering Graduate Program, University of Kansas, Lawrence, KS, USA.
Department of Plastic Surgery, University of Kansas Medical Center, Kansas City, KS, USA.
Biomater Res. 2022 Oct 1;26(1):50. doi: 10.1186/s40824-022-00291-5.
Wound healing is a dynamic series of interconnected events with the ultimate goal of promoting neotissue formation and restoration of anatomical function. Yet, the complexity of wound healing can often result in development of complex, chronic wounds, which currently results in a significant strain and burden to our healthcare system. The advancement of new and effective wound care therapies remains a critical issue, with the current therapeutic modalities often remaining inadequate. Notably, the field of tissue engineering has grown significantly in the last several years, in part, due to the diverse properties and applications of polymeric biomaterials. The interdisciplinary cohesion of the chemical, biological, physical, and material sciences is pertinent to advancing our current understanding of biomaterials and generating new wound care modalities. However, there is still room for closing the gap between the clinical and material science realms in order to more effectively develop novel wound care therapies that aid in the treatment of complex wounds. Thus, in this review, we discuss key material science principles in the context of polymeric biomaterials, provide a clinical breadth to discuss how these properties affect wound dressing design, and the role of polymeric biomaterials in the innovation and design of the next generation of wound dressings.
伤口愈合是一系列动态的相互关联的事件，其最终目标是促进新组织形成和恢复解剖功能。然而，伤口愈合的复杂性常常导致复杂慢性伤口的出现，这目前给我们的医疗系统带来了巨大的压力和负担。新型有效伤口护理疗法的进展仍然是一个关键问题，当前的治疗方式往往仍显不足。值得注意的是，在过去几年中，组织工程领域有了显著发展，部分原因是聚合物生物材料具有多样的特性和应用。化学、生物学、物理学和材料科学的跨学科融合对于推进我们目前对生物材料的理解以及开发新的伤口护理方式至关重要。然而，为了更有效地开发有助于治疗复杂伤口的新型伤口护理疗法，在临床和材料科学领域之间缩小差距仍有空间。因此，在本综述中，我们在聚合物生物材料的背景下讨论关键的材料科学原理，从临床广度探讨这些特性如何影响伤口敷料设计，以及聚合物生物材料在下一代伤口敷料的创新和设计中的作用。
