Department of Transfusion, The Affiliated Hospital of Southwest Medical University, 25 Taiping Road, Luzhou, Sichuan, 646000, People's Republic of China.
Department of Clinical Laboratory, The First People's Hospital of Longquanyi District, Chengdu, 201 Third Yihe Group, Longquanyi District, Chengdu, Sichuan, 610100, People's Republic of China.
AIDS Res Ther. 2021 Apr 5;18(1):11. doi: 10.1186/s12981-021-00330-6.
The widely-expressed molecule CD38 is a single-stranded type II transmembrane glycoprotein that is mainly involved in regulating the differentiation and activation state of the cell. CD38 has broad and complex functions, including enzymatic activity, intercellular signal transduction, cell activation, cytokine production, receptor function and adhesion activity, and it plays an important role in the physiological and pathological processes of many diseases. Many studies have shown that CD38 is related to the occurrence and development of HIV infection, and CD38 may regulate its progression through different mechanisms. Therefore, investigating the role of CD38 in HIV infection and the potential signaling pathways that are involved may provide a new perspective on potential treatments for HIV infection. In the present review, the current understanding of the roles CD38 plays in HIV infection are summarized. In addition, the specific role of CD38 in the process of HIV infection of human CD4 T lymphocytes is also discussed.
广泛表达的分子 CD38 是一种单链 II 型跨膜糖蛋白，主要参与调节细胞的分化和激活状态。CD38 具有广泛而复杂的功能，包括酶活性、细胞间信号转导、细胞激活、细胞因子产生、受体功能和黏附活性，它在许多疾病的生理和病理过程中发挥着重要作用。许多研究表明，CD38 与 HIV 感染的发生和发展有关，CD38 可能通过不同的机制调节其进展。因此，研究 CD38 在 HIV 感染中的作用及其潜在的信号通路可能为 HIV 感染的潜在治疗提供新的视角。在本综述中，总结了目前对 CD38 在 HIV 感染中作用的认识。此外，还讨论了 CD38 在 HIV 感染人 CD4 T 淋巴细胞过程中的具体作用。
