Peiffer G, Underner M, Perriot J, Fond G
Service de pneumologie - tabacologie, CHR Metz-Thionville, 57085 Metz cedex 3, France.
Unité de recherche clinique, université de Poitiers, centre hospitalier Henri-Laborit, 86021 Poitiers, France.
Rev Mal Respir. 2021 Apr;38(4):357-371. doi: 10.1016/j.rmr.2021.03.004. Epub 2021 Apr 2.
COPD is a chronic respiratory disease, often associated with extrapulmonary manifestations. Co-morbidities, including anxiety, depression and cognitive impairment, worsen its progression and quality of life. The prevalence of these disorders is high, yet they are often poorly understood and inadequately managed. In the development of psychological disorders, there is accumulated evidence highlighting the major role of systemic inflammation, as well as chronic disease, genetics, the consequences of smoking, hypoxaemia, oxidative stress, and the gut microbiome In addition to traditional treatments such as bronchodilatator medications, respiratory rehabilitation and smoking cessation, systemic inflammation is an interesting therapeutic target, with the use of anti-inflammatory drugs, anti-cytokines, and nutritional interventions.
慢性阻塞性肺疾病（COPD）是一种慢性呼吸道疾病，常伴有肺外表现。包括焦虑、抑郁和认知障碍在内的合并症会加剧其病情进展并影响生活质量。这些疾病的患病率很高，但人们对它们的了解往往不足，管理也不够充分。在心理障碍的发展过程中，越来越多的证据表明全身炎症、慢性疾病、遗传学、吸烟后果、低氧血症、氧化应激和肠道微生物群起主要作用。除了使用支气管扩张剂药物、呼吸康复和戒烟等传统治疗方法外，全身炎症是一个有趣的治疗靶点，可使用抗炎药物、抗细胞因子和营养干预措施。
