瑞士人源和零售鸡肉源耐黏菌素大肠杆菌分离株中 的异质性遗传定位：携带 - 的 IncK2 质粒的出现。
Heterogeneous Genetic Location of in Colistin-Resistant Escherichia coli Isolates from Humans and Retail Chicken Meat in Switzerland: Emergence of -Carrying IncK2 Plasmids.
机构信息
Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
Graduate School of Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
出版信息
Antimicrob Agents Chemother. 2017 Oct 24;61(11). doi: 10.1128/AAC.01245-17. Print 2017 Nov.
Abstract
We characterized the genetic environment of in colistin-resistant strains isolated in Switzerland during 2014 to 2016 from humans ( = 3) and chicken meat ( = 6). Whole-genome and plasmid sequencing identified the gene integrated in IncX4 (of which, one strain carried the variant), IncI2, IncHI2, and novel IncK2 plasmids (overall, = 7), as well as in the bacterial chromosome ( = 2) in single or duplicate copies. Our study supports the easy mobilization of across diverse genetic locations.
摘要
我们对瑞士在 2014 年至 2016 年间从人类（n=3）和鸡肉（n=6）中分离出的粘菌素耐药 菌株的遗传环境进行了研究。全基因组和质粒测序确定了 基因整合在 IncX4 中（其中一个菌株携带 变体）、IncI2、IncHI2 和新型 IncK2 质粒（总共 n=7），以及细菌染色体（n=2）中的单个或重复拷贝。我们的研究支持了 在不同遗传位置之间的易移动性。
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